Comparison of the Effects of Protocols Applied After Surgical Extraction of Impacted Mandibular Third Molars
NCT ID: NCT06900907
Last Updated: 2025-03-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
75 participants
INTERVENTIONAL
2017-03-01
2017-09-22
Brief Summary
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Detailed Description
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Corticosteroids exert their anti-inflammatory effects by inhibiting both the function and production of certain inflammatory cells. Therefore, they have been widely used for many years to reduce complications following impacted third molar surgery. Low-level laser therapy (LLLT) has anti-inflammatory and analgesic properties, as well as a biostimulatory effect that promotes wound healing. Ozone therapy, due to its antibacterial and anti-inflammatory properties, as well as its ability to accelerate epithelial healing, has been recognized in the literature as a modern, drug-free alternative for managing postoperative complications.
Hyaluronic acid (HA) is a member of the glycosaminoglycan family found in various body tissues. Due to its numerous advantages, including the promotion of wound healing, anti-inflammatory, bacteriostatic, and osteoinductive effects, it plays a crucial role in tissue healing and the prevention of postoperative sequelae.
This study comparatively evaluates the efficacy of low-level laser therapy, hyaluronic acid, ozone therapy, and methylprednisolone in preventing complications such as pain, edema, and trismus following impacted mandibular third molar surgery, with the aim of improving patients' quality of life.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Group 1 Laser
In Group 1, after the extraction of the impacted third molar, a diode laser (Epic X, Biolase, USA) with a wavelength of 940 nm and power of 0.2 W was applied in non-contact mode for 25 seconds at an energy density of 10 J/cm² to the occlusal, buccal, and lingual surfaces of the extraction site.
Diode laser
A single session was applied to three points of the tooth extraction site.
Group 2 Hyaluronic acid
In Group 2, after the extraction of the impacted third molar, 1 cc of high-molecular-weight hyaluronic acid gel (240 mg/100 g) (Bioplax, London, UK) was placed into the extraction socket.
Hyaluronic acid
1 cc of hyaluronic acid gel was placed into the extraction socket, followed by suturing.
Group 3 Ozone
In Group 3, after the extraction of the impacted third molar, topical ozone therapy (W\&H Prozone Ozone Generator) was applied to the extraction socket for 15 seconds.
Ozone
Topical ozone was applied to the extraction socket, followed by suturing.
Group 4 Methylprednisolone
In Group 4, in addition to the standard prescribed medication, patients received 4 mg oral methylprednisolone (Koçak Farma İlaç ve Kimya Sanayi A.Ş., Istanbul) starting immediately after surgery. It was administered three times on the first day, twice on the second day, and once on the third day.
Methylprednisolone
In addition to the standard prescribed medication, 4 mg of oral methylprednisolone was prescribed postoperatively.
Group 5 Control
In Group 5 (control group), only the standard prescribed medication was provided.
Control
Only the standard prescribed medication was provided.
Interventions
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Diode laser
A single session was applied to three points of the tooth extraction site.
Hyaluronic acid
1 cc of hyaluronic acid gel was placed into the extraction socket, followed by suturing.
Ozone
Topical ozone was applied to the extraction socket, followed by suturing.
Methylprednisolone
In addition to the standard prescribed medication, 4 mg of oral methylprednisolone was prescribed postoperatively.
Control
Only the standard prescribed medication was provided.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age range of 18-35 years
* Individuals of both genders
* Horizontally impacted teeth with the same angulation according to Winter's classification
Exclusion Criteria
* Pregnant or breastfeeding women
* Smokers
* Individuals with allergic reactions to the adjuvants or prescribed medications used in the study
* Surgical extraction procedures exceeding 30 minutes
18 Years
35 Years
ALL
Yes
Sponsors
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Batman University
OTHER
Responsible Party
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Rojdan Ferman GÜNEŞ UYSAL
Assistant professor
Principal Investigators
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Nedim GÜNEŞ, Ass.Prof.
Role: STUDY_CHAIR
Dicle University
Locations
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Dicle University
Diyarbakır, Sur, Turkey (Türkiye)
Countries
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Other Identifiers
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DİŞ.15.023
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
BatmanU-DF-RFGU-03
Identifier Type: -
Identifier Source: org_study_id
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