Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-04-30

Study Completion Date

2011-12-31

Brief Summary

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The main aim of the present study was to investigate the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.

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Detailed Description

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Third molar surgery is often associated with significant post-surgical sequelae. The trauma caused to soft and bony tissue can result in considerable pain, swelling and trismus. Symptoms begin gradually having a peak 2 days after extraction. The use of corticosteroids such as dexamethasone and methylprednisolone can be a valuable tool when performing moderate to moderately severe oral surgical procedures. No clear consensus have emerged yet regarding patient selection, dosage, timing and type of administration of steroid. In this light, this clinical trial aim to compare the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.

Conditions

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Pain, Edema, Trismus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Dexamethasone 8mg

Group Type EXPERIMENTAL

Dexamethasone

Intervention Type DRUG

Dexamethasone 8mg

Methylprednisolone

Methylprednisolone 40mg

Group Type EXPERIMENTAL

Methylprednisolone

Intervention Type DRUG

Methylprednisolone 40mg

Interventions

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Dexamethasone

Dexamethasone 8mg

Intervention Type DRUG

Methylprednisolone

Methylprednisolone 40mg

Intervention Type DRUG

Other Intervention Names

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Dexametasone acetate

Eligibility Criteria

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Inclusion Criteria

* Patients with indication of asymptomatic bilateral extractions of lower third molars
* Aged 18 years or older;
* Have a good health and no disease;

Exclusion Criteria

* Patients with history of any medication treatment within 15 days before the beginning of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No