Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain
NCT ID: NCT06894069
Last Updated: 2025-03-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
EARLY_PHASE1
80 participants
INTERVENTIONAL
2025-03-31
2025-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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DXM
Patients in this group will receive a standard root canal treatment but with the extra step of extruding a Dexamethasone (DXM) solution through the root canals to the periradicular tissues prior to obturation.
Dexamethasone
a 2 ml solution of dexamethasone (3.3mg/ml) will be flushed in the root canal and intentionally extruded to the periradicular tissues to assess its potnetial sedative effect
Saline
Patients in this group will receive a standard root canal treatment with saline used as the final irrigating solution prior to obturation.
Placebo
2ml of normal saline will be used as placebo to be flushed and extruded through the canals to the periradicular tissues
Interventions
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Dexamethasone
a 2 ml solution of dexamethasone (3.3mg/ml) will be flushed in the root canal and intentionally extruded to the periradicular tissues to assess its potnetial sedative effect
Placebo
2ml of normal saline will be used as placebo to be flushed and extruded through the canals to the periradicular tissues
Eligibility Criteria
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Inclusion Criteria
* Adult patients (aged 18 - 70)
* Healthy patients or those with a well-controlled disease (ASA I \& II)
Exclusion Criteria
* Patients with a severe systemic disease (ASA III or higher)
* Patients who received analgesics12 hours before presentation
* Previously treated/initiated Endodontics treatment on the same tooth
* Unopposed teeth
* Third molar teeth
* Non-restorable teeth
* Periodontally compromised teeth
* Pregnant or lactating patients
18 Years
70 Years
ALL
No
Sponsors
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University of Jordan
OTHER
Responsible Party
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Renad Hazem Khanfer
Doctor
Central Contacts
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Ahmad M El Ma'aita
Role: CONTACT
Other Identifiers
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10/2023/ 32001
Identifier Type: -
Identifier Source: org_study_id
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