Effects of Melatonin and Massage After Third Molar Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-01

Study Completion Date

2026-05-10

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Lymphatic drainage massage is an important practice, especially for reducing edema. It is a very gentle, monotonous, slow, rhythmic massage applied to the skin surface. It accelerates the flow of lymph fluid and provides comfort by minimizing swelling. Lymphatic drainage massage, which is frequently used after impacted third molar surgery, helps reduce edema and increases patient comfort during the postoperative period.

Melatonin, a hormone produced by the pineal gland, is a neurochemical substance that works in harmony with the body's natural rhythm. In addition to the brain, it is found in the retina, bone marrow, intestines, skin, and various blood cells. Conditions such as insomnia or jet lag may benefit from melatonin supplements. Besides contributing to sleep quality, melatonin may also assist in regulating the immune system, body temperature, blood pressure, and cortisol hormone levels.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Manual Massage Technique on Swelling, Pain and Mouth Opening After Bilateral Lower Third Molar Surgery

NCT06787027

Impacted Third Molar Tooth Swelling/ Edema Pain +1 more

COMPLETED NA

The Effect of Saline Irrigation at Different Temperatures on Pain, Edema, and Trismus After Impacted Third Molar Surgery

NCT05170516

Impacted Third Molar Tooth

COMPLETED NA

Negative Pressure Wound Therapy in Oral Surgery

NCT06758258

Edema Postoperative Pain Postoperative Complications

COMPLETED NA

Is Therapeutic Elastic Bandage As Effective As Corticosteroids Following Third Molar Surgery?

NCT04200885

Third Molar Surgery

COMPLETED PHASE4

Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus

NCT04534426

Impacted Third Molar Tooth

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Another important function of melatonin is that it is a very powerful free radical scavenger. Melatonin can neutralize both reactive oxygen species and reactive nitrogen species. It is also known to capture highly toxic hydroxyl radicals, peroxynitrite anions, and peroxyl radicals. In some cases, melatonin inhibits nitric oxide synthase, a prooxidant enzyme. Additionally, it stimulates the mRNA levels of superoxide dismutase enzyme and is known to activate glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase. After reacting with the hydroxyl free radical (OH•), melatonin transforms into an indolyl cation radical, which is noted to capture the superoxide radical (O2 · -) in the environment and exhibit antioxidant activity. Due to this powerful antioxidant property, its effects on pain and edema have been investigated in some studies. In these studies, pre-op/post-op melatonin application has been shown to reduce postoperative pain and accelerate sensory healing due to melatonin's antioxidant effects.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Melatonin

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

control

during the postoperative period receive any lymphatic drainage massage and melatonin

no melatonin and massage

Intervention Type OTHER

receiving no melatonin and massage

study melatonin

during the postoperative period receive only melatonin pills

receive melatonin

Intervention Type DIETARY_SUPPLEMENT

receiving only melatıonin pills

study lymphatic drainage massage

during the postoperative period receive only lymphatic drainage massage

receiving lymphatic drainage

Intervention Type OTHER

receiving lymphatic drainage massage

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

no melatonin and massage

receiving no melatonin and massage

Intervention Type OTHER

receive melatonin

receiving only melatıonin pills

Intervention Type DIETARY_SUPPLEMENT

receiving lymphatic drainage

receiving lymphatic drainage massage

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients need for removal surgery of impacted third molars.
2. Patients without systemic diseases.

Exclusion Criteria

1. Presence of systemic diseases affecting general health.
2. Presence of a malignant disease in the head and neck region.
3. Patients with any bleeding disorders.
4. Patients with cardiovascular diseases or those undergoing anticoagulant or antiplatelet therapy.

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes