Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery

NCT ID: NCT06900894

Last Updated: 2025-04-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 44 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-10-01
• Study Completion Date: 2024-05-21

Brief Summary

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Detailed Description

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in postoperative management following impacted mandibular third molar surgery. Postoperative complications, such as pain and edema, are commonly observed and may impact patient comfort and recovery. This study aims to evaluate the feasibility of two non-pharmacological approaches-PRF and Kinesio Taping (Elastic Bandaging)-in postoperative care.

A total of 44 patients aged 18-35 years participated in this prospective, randomized clinical trial. Patients were assigned to one of three groups:

PRF Group: Platelet-rich fibrin (PRF) was applied locally into the extraction socket.

Kinesio Taping Group: An elastic bandage was applied postoperatively to the surgical area and removed on the third day.

Control Group: Standard postoperative care was provided with no additional intervention.

Postoperative evaluations were conducted on the 3rd and 7th days. The measured parameters included:

Edema: Measured using anthropometric techniques.

Pain: Assessed with the Numerical Rating Scale (NRS).

Quality of Life: Evaluated using the Oral Health Impact Profile-14 (OHIP-14).

This study aims to assess the feasibility of PRF and Kinesio Taping in postoperative management.

Conditions

Impacted Third Molar Tooth; Postoperative Pain; Postoperative Edema

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

PRF Group

Participants in this group received Platelet-Rich Fibrin (PRF) applied to the extraction socket following impacted third molar surgery. PRF was prepared using a centrifugation protocol and placed into the surgical site.

Group Type: EXPERIMENTAL

Platelet-Rich Fibrin (PRF)

Intervention Type: BIOLOGICAL

PRF was prepared using a centrifugation protocol and applied to the extraction socket.

Kinesio Taping Group

Participants in this group received Kinesio Taping applied postoperatively. The elastic therapeutic tape was applied to the masseter and submandibular region following a standardized taping protocol.

Group Type: EXPERIMENTAL

Kinesio Taping

Intervention Type: DEVICE

Kinesio Tape was applied postoperatively to the masseter and submandibular region.

Control Group

Participants in this group received standard postoperative care, including routine pain management and wound care, without additional interventions.

Group Type: OTHER

Standard Postoperative Care

Intervention Type: OTHER

Patients in the control group received standard postoperative care.

Interventions

Platelet-Rich Fibrin (PRF)

PRF was prepared using a centrifugation protocol and applied to the extraction socket.

Intervention Type: BIOLOGICAL

Kinesio Taping

Kinesio Tape was applied postoperatively to the masseter and submandibular region.

Intervention Type: DEVICE

Standard Postoperative Care

Patients in the control group received standard postoperative care.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Ages 18-35 years
• Systemically healthy individuals
• Non-smokers
• No psychological disorders
• Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
• No preoperative edema in the surgical area
• Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
• Signed an informed consent form

Exclusion Criteria

• Under 18 or over 35 years old
• Presence of chronic or systemic diseases
• Pregnant or breastfeeding patients
• Surgical duration exceeding 45 minutes
• Smokers
• Patients requiring prophylactic antibiotics due to systemic health conditions
• Patients who did not meet the study criteria or did not sign the informed consent form

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mustafa Kemal University

OTHER

Sponsor Role: lead

Responsible Party

züleyha başar karakuzu

DDS, Oral and Maxillofacial Surgeon

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

züleyha başar karakuzu, DDS

Role: PRINCIPAL_INVESTIGATOR

Mustafa Kemal University

Locations

Hatay Mustafa Kemal University, Faculty of Dentistry

Hatay, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

Ethics Committee No.

Identifier Type: REGISTRY

Identifier Source: secondary_id

PRF_KT2025

Identifier Type: -

Identifier Source: org_study_id