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The Use of Platelet-rich-fibrin in Lower Third Molar Surgery.

NCT ID: NCT06165692

Last Updated: 2023-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-01

Study Completion Date

2023-10-31

Brief Summary

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The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Detailed Description

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The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial. Facial swelling will be assessed using an innovative three-dimensional digital technique.

Conditions

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Facial Swelling Tooth Position Anomalies Tooth, Impacted Tooth Extraction Status Nos Tooth Avulsion

Keywords

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third molar surgery facial swelling 3D facial swelling evaluation PRF tooth impacted platelet rich fibrin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Test Group

Placement of PRF in the post-extraction socket after third molar surgery

Group Type EXPERIMENTAL

PRF

Intervention Type BIOLOGICAL

Post-operative PRF placement in the post-extraction socket after third molar surgery

Control Group

No positioning PRF in the post-extraction socket after third molar surgery

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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PRF

Post-operative PRF placement in the post-extraction socket after third molar surgery

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patients aged 18 to 32 years who required both M3M extractions were recruited
* Good health status
* Indication to surgical extraction of both M3M
* Complete root formation
* Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification

Exclusion Criteria

* Person under the age of 18 or over 32
* Allergy or contraindications to administration of corticosteroids
* Acute infection in any of the teeth to be extracted
* Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease
* Pregnancy or breastfeeding
* History of treatment with antiresorptive drugs
* Chronic kidney disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

32 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Amerigo Giudice

OTHER

Sponsor Role lead

Responsible Party

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Amerigo Giudice

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Magna Graecia University of Catanzaro

Catanzaro, , Italy

Site Status

Countries

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Italy

Other Identifiers

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2/2023

Identifier Type: -

Identifier Source: org_study_id