Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
21 participants
INTERVENTIONAL
2024-12-02
2025-05-30
Brief Summary
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The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).
Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Isometric exercise without BFR cuff (control)
Isometric handgrip exercise
The participants will perform isometric handgrip exercises without blood flow restriction.
Isometric exercise with narrow-elastic BFR band
Isometric handgrip exercise with a narrow-elastic band
The participants will perform isometric handgrip exercises with blood flow restriction using a narrow-elastic band.
Isometric exercise with wide-rigid BFR cuff
Isometric handgrip exercise with a wide-rigid cuff
The participants will perform isometric handgrip exercises with blood flow restriction using a wide-rigid cuff.
Interventions
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Isometric handgrip exercise
The participants will perform isometric handgrip exercises without blood flow restriction.
Isometric handgrip exercise with a narrow-elastic band
The participants will perform isometric handgrip exercises with blood flow restriction using a narrow-elastic band.
Isometric handgrip exercise with a wide-rigid cuff
The participants will perform isometric handgrip exercises with blood flow restriction using a wide-rigid cuff.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Acid-base imbalance/acidosis
* Arterial calcification
* Atherosclerotic vessels
* Cardiopulmonary conditions
* Diabetes
* Dialysis/central venous access
* General/local infection
* High intracranial pressure
* Hip, pelvis, or femur fracture
* History of venous thromboembolism
* Hypertension
* Immobility for greater than 48 hours in the past month
* Immobilizing cast
* Implanted medical device
* Lymphectomies
* Obesity
* Open fracture
* Open or unhealed soft tissue injuries
* Paralysis
* Peripheral vascular disease
* Pregnancy/postpartum
* Prior revascularization
* Renal compromise
* Severe crush injuries
* Sickle cell trait/anemia
* Skin grafts
* Stroke
* Temporary nerve damage
* Thrombophilia
* Tumor/cancer
* Varicose veins
* Vascular grafting
18 Years
40 Years
ALL
Yes
Sponsors
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University of Texas at Austin
OTHER
Responsible Party
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Locations
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Cardiovascular Aging Research Laboratory
Austin, Texas, United States
Countries
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References
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Lind AR. Cardiovascular responses to static exercise. (Isometrics, anyone?). Circulation. 1970 Feb;41(2):173-6. doi: 10.1161/01.cir.41.2.173. No abstract available.
Domingos E, Polito MD. Blood pressure response between resistance exercise with and without blood flow restriction: A systematic review and meta-analysis. Life Sci. 2018 Sep 15;209:122-131. doi: 10.1016/j.lfs.2018.08.006. Epub 2018 Aug 4.
Bond CW, Hackney KJ, Brown SL, Noonan BC. Blood Flow Restriction Resistance Exercise as a Rehabilitation Modality Following Orthopaedic Surgery: A Review of Venous Thromboembolism Risk. J Orthop Sports Phys Ther. 2019 Jan;49(1):17-27. doi: 10.2519/jospt.2019.8375. Epub 2018 Sep 12.
Mannozzi J, Al-Hassan MH, Kaur J, Lessanework B, Alvarez A, Massoud L, Aoun K, Spranger M, O'Leary DS. Blood flow restriction training activates the muscle metaboreflex during low-intensity sustained exercise. J Appl Physiol (1985). 2023 Aug 1;135(2):260-270. doi: 10.1152/japplphysiol.00274.2023. Epub 2023 Jun 22.
Song JS, Yamada Y, Wong V, Bell ZW, Spitz RW, Abe T, Loenneke JP. Hypoalgesia following isometric handgrip exercise with and without blood flow restriction is not mediated by discomfort nor changes in systolic blood pressure. J Sports Sci. 2022 Mar;40(5):518-526. doi: 10.1080/02640414.2021.2003569. Epub 2021 Nov 25.
Renzi CP, Tanaka H, Sugawara J. Effects of leg blood flow restriction during walking on cardiovascular function. Med Sci Sports Exerc. 2010 Apr;42(4):726-32. doi: 10.1249/MSS.0b013e3181bdb454.
Early KS, Rockhill M, Bryan A, Tyo B, Buuck D, McGinty J. EFFECT OF BLOOD FLOW RESTRICTION TRAINING ON MUSCULAR PERFORMANCE, PAIN AND VASCULAR FUNCTION. Int J Sports Phys Ther. 2020 Dec;15(6):892-900. doi: 10.26603/ijspt20200892.
Credeur DP, Hollis BC, Welsch MA. Effects of handgrip training with venous restriction on brachial artery vasodilation. Med Sci Sports Exerc. 2010 Jul;42(7):1296-302. doi: 10.1249/MSS.0b013e3181ca7b06.
Schneider AC, Hughes WE, Ueda K, Bock JM, Casey DP. Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation. Nitric Oxide. 2018 Aug 1;78:81-88. doi: 10.1016/j.niox.2018.05.010. Epub 2018 Jun 1.
Other Identifiers
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STUDY00006378
Identifier Type: -
Identifier Source: org_study_id
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