Bioavailability of Orally Ingested Vitamin C

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-26

Study Completion Date

2023-11-26

Brief Summary

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The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Crystalline vitamin C supplementation

1000 mg of vitamin C ingested in crystalline form

Group Type ACTIVE_COMPARATOR

Crystalline vitamin C

Intervention Type DIETARY_SUPPLEMENT

Ingesting 1000 mg of vitamin C in crystalline form

Phosphatidylcholine-lipid encapsulated vitamin C supplementation

1000 mg of vitamin C ingested in phosphatidylcholine-lipid encapsulated form

Group Type EXPERIMENTAL

Phosphatidylcholine-lipid encapsulated vitamin C

Intervention Type DIETARY_SUPPLEMENT

Ingesting 1000 mg of vitamin C in phosphatidylcholine-lipid encapsulated form

Interventions

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Phosphatidylcholine-lipid encapsulated vitamin C

Ingesting 1000 mg of vitamin C in phosphatidylcholine-lipid encapsulated form

Intervention Type DIETARY_SUPPLEMENT

Crystalline vitamin C

Ingesting 1000 mg of vitamin C in crystalline form

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Body mass index (BMI) 18.5 - 30 kg/m2
* Age 18 - 40
* Non-smoker

Exclusion Criteria

* Body mass index (BMI) \< 18.5 or \> 30 kg/m2
* Age \< 18 or \> 40
* Smoking
* Cardiovascular disease
* Hypertension (≥ 140/90 mmHg)
* Metabolic disease
* Medications known to affect vitamin C metabolism
* A known vitamin C deficiency
* Less than 2 hours per week of physical activity or following a structured exercise training program.
* Routine use of vitamin supplements

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes