Resistance Training and Hydrolyzed Collagen Supplementation in Middle-aged Adults

NCT ID: NCT06402890

Last Updated: 2024-05-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-07-01
• Study Completion Date: 2023-07-13

Brief Summary

The aim of this clinical trial is to investigate the longitudinal effects of hydrolyzed collagen ingestion combined with resistance training on muscle-tendon unit structure and function in middle-aged males and females.

The main research questions this clinical trial aims to answer are:

1. Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone in middle-aged health men and women?

2. Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone?

3. Does resistance training with hydrolyzed collagen lead to greater increases in strength and power compared to resistance training alone in middle-aged, healthy men and women?

Participants will be randomly assigned to collagen or placebo groups. Participants will perform 24 sessions of high intensity resistance training across 12-weeks. Alongside each training session, participants will consume a beverage containing hydrolyzed collagen or maltodextrin, with both beverages containing vitamin C.

Researchers will compare the collagen and placebo groups to see if there would be beneficial effects on changes in muscle and tendon that are greater than resistance training alone. To achieve this, an dynamometry will be used to assess lower limb strength and ultrasound will be used to measure the morphological, mechanical, and material properties of the patellar tendon, as well the size and architecture of the vastus lateralis muscle.

Detailed Description

Healthy, active, middle-aged men and women will ingest a beverage containing 30 g of hydrolyzed collagen with 50 mg of vitamin C or a calorie matched beverage (maltodextrin), also with 50 mg of vitamin C combined with high-volume, high-intensity resistance training for the lower body on 2 - 3 occasions per week for 8-12 weeks.

The aim of this study was to investigate the effect of combining hydrolyzed collagen with resistance training in middle-aged men and women.If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance. This is the first study to investigate the combination of hydrolyzed collage supplementation with resistance training in middle-aged men and women. If supplementation with hydrolyzed leads to greater improvements in tendon size, stiffness, strength and/or power, this will allow us to recommend this type of intervention to middle-aged athletes/trainees seeking to improve tendon health, reduce injury risk, or enhance athletic performance.

The experimental design of both arms will be the same, however Arm 1 will be health, middle-aged male participants and Arm 2 will be health, middle-aged female participants.

Conditions

Diet; Food; Nutrition

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: TRIPLE

Study Groups

Resistance training with hydrolyzed collagen in health, active, middle-aged men

Middle-aged, trained males completed 12-weeks of a supervised, progressive resistance training programme while consuming 30 g of hydrolyzed collagen or a calorie matched placebo beverage.

Group Type: EXPERIMENTAL

Resistance training with collagen supplementation

Intervention Type: DIETARY_SUPPLEMENT

Participants performed 24 lower limb resistance training sessions over under supervision from the principal investigator. Participants were pair-matched, then allocated to hydrolysed collagen (COL) or a calorie-matched beverage comprising maltodextrin and non-caloric sweetener (PLA). Both COL and PLA consumed their respective supplements in conjunction with each resistance training session.

Baseline assessments of strength were used to set initial training loads. An example of weekly training is included below for indicative purposes:

Week 1 protocol:

Day 1:

• Barbell squat, 4 sets @ 90% 10-RM
• Romanian deadlift, 4 sets @ 90% 10-RM

Day 2:

• Hex bar deadlift, 4 sets @ 90% 10-RM
• Dumbbell goblet squat, 4 sets @ 90% 10-RM

Linear progression adjusted weekly loads. If participants completed the prescribed sets and reps, loads increased by 2.5-5 % the following week.

Resistance training with hydrolyzed collagen in healthy, active, middle-aged women

Middle-aged, trained females completed 8-weeks of a supervised, progressive resistance training programme while consuming 30 g of hydrolyzed collagen or a calorie matched placebo beverage

Group Type: EXPERIMENTAL

Resistance training with collagen supplementation

Intervention Type: DIETARY_SUPPLEMENT

Participants performed 24 lower limb resistance training sessions over under supervision from the principal investigator. Participants were pair-matched, then allocated to hydrolysed collagen (COL) or a calorie-matched beverage comprising maltodextrin and non-caloric sweetener (PLA). Both COL and PLA consumed their respective supplements in conjunction with each resistance training session.

Baseline assessments of strength were used to set initial training loads. An example of weekly training is included below for indicative purposes:

Week 1 protocol:

Day 1:

• Barbell squat, 4 sets @ 90% 10-RM
• Romanian deadlift, 4 sets @ 90% 10-RM

Day 2:

• Hex bar deadlift, 4 sets @ 90% 10-RM
• Dumbbell goblet squat, 4 sets @ 90% 10-RM

Linear progression adjusted weekly loads. If participants completed the prescribed sets and reps, loads increased by 2.5-5 % the following week.

Interventions

Resistance training with collagen supplementation

Participants performed 24 lower limb resistance training sessions over under supervision from the principal investigator. Participants were pair-matched, then allocated to hydrolysed collagen (COL) or a calorie-matched beverage comprising maltodextrin and non-caloric sweetener (PLA). Both COL and PLA consumed their respective supplements in conjunction with each resistance training session.

Baseline assessments of strength were used to set initial training loads. An example of weekly training is included below for indicative purposes:

Week 1 protocol:

Day 1:

• Barbell squat, 4 sets @ 90% 10-RM
• Romanian deadlift, 4 sets @ 90% 10-RM

Day 2:

• Hex bar deadlift, 4 sets @ 90% 10-RM
• Dumbbell goblet squat, 4 sets @ 90% 10-RM

Linear progression adjusted weekly loads. If participants completed the prescribed sets and reps, loads increased by 2.5-5 % the following week.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Recreationally active or competing in Masters sport
• No history of patellar tendon injuries in the past 6 months
• No history of lower limb musculoskeletal injuries in the past 6 months
• Non-smokers (including e-cigarettes)
• Free from cardiovascular and metabolic diseases

Exclusion Criteria

• Age < 35 years or > 59 years
• Being vegan or vegetarian (due to the mammalian source of collagen)
• Injury history incompatible with lower body resistance training
• Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)
• BMI over 30 kg/m2

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 59 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Liverpool John Moores University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Robert M Erskine, PhD

Role: STUDY_DIRECTOR

Liverpool John Moores University

Christopher D Nulty, MSc

Role: PRINCIPAL_INVESTIGATOR

Liverpool John Moores University

Locations

Dr Rob Erskine

Liverpool, , United Kingdom

Countries

United Kingdom

Provided Documents

Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Other Identifiers

300

Identifier Type: -

Identifier Source: org_study_id