Effect of Collagen Supplementation on Tendinopathy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-16

Study Completion Date

2025-05-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Tendon injuries represent a significant problem in elite athletes. Therefore, prevention and effective treatment of tendon overload injury/tendinopathy is important. Among different treatment options, heavy-slow loading based rehabilitation is considered among the most efficient treatments in athletes. In this study, we will investigate if supplementation with hydrolyzed collagen in combination with a heavy-slow loading based 12 weeks rehabilitation regime can improve treatment of tendon overload injury/tendinopathy. The investigators will examine elite athletes with overload injury/tendinopathy with regards to symptoms (pain, function), tendon morphology (ultrasonography), and vascularization (Doppler US). The investigators hypothesize that collagen supplementation can have an improving effect on tendon pain and function. Thus, the investigation will show if a rehabilitation regime of collagen supplementation combined with heavy-slow mechanical loading can improve tendon healing compared to mechanical loading alone.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effects of Omega-3 Status and Supplementation on Tendon Structure in Competitive Athletes

NCT03880149

Tendon Injuries Inflammation

UNKNOWN NA

Collagen Peptide Supplementation and Lifelong Athletes

NCT05751005

Pain

COMPLETED NA

Resistance Training and Hydrolyzed Collagen Supplementation in Middle-aged Adults

NCT06402890

Diet Food Nutrition

COMPLETED NA

Muscle-Tendon Mechanics During Locomotor Tasks, Efficacy of Collagen Supplementation for Older Adults

NCT03563261

Tendon Stiffness With Age

COMPLETED NA

Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults

NCT06372080

Healthy Participants Nutrition Exercise Training

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Randomized placebo-controlled intervention study with follow-up after one month

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tendinopathy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Collagen + heavy slow resistance group

Daily collagen supplementation + heavy slow resistance training three times weekly for 12 weeks.

Group Type ACTIVE_COMPARATOR

Hydrolyzed collagen

Intervention Type DIETARY_SUPPLEMENT

Hydrolyzed collagen supplementation twice daily

Heavy slow resistance training

Intervention Type OTHER

Heavy slow resistance training 3 times weekly

Placebo + heavy slow resistance group

Daily placebo supplementation + heavy slow resistance training three times weekly for 12 weeks.

Group Type EXPERIMENTAL

Heavy slow resistance training

Intervention Type OTHER

Heavy slow resistance training 3 times weekly

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo supplementation twice daily

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Hydrolyzed collagen

Hydrolyzed collagen supplementation twice daily

Intervention Type DIETARY_SUPPLEMENT

Heavy slow resistance training

Heavy slow resistance training 3 times weekly

Intervention Type OTHER

Placebo

Placebo supplementation twice daily

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Elite athletes
* 18-40 years old
* Exercise related tendon pain on one or both legs
* Soreness during physical examination of tendon upon palpation
* Uni- or bilateral tendinopathy symptoms \> 3 months

Exclusion Criteria

* Previous tendon surgery
* Diabetes
* Arthritis
* Corticosteroid injection for tendinopathy within the last 3 months
* Any form of tendon injection within the last 3 months
* Smoking

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No