Effects of Oral Supplementation of Arginine, Zinc and Vitamin C on Collagen Synthesis in Inguinal Hernia Patients
NCT ID: NCT03221686
Last Updated: 2018-06-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2016-02-20
2017-12-10
Brief Summary
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The aim of this study is to investigate the effect of a pre and postoperative oral supplement consisting of arginine, zinc and vitamin C on collagen synthesis in patients undergoing inguinal hernia repair.
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Detailed Description
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The patients in the intervention group are given 55 mg zinc, 1251 mg vitamin C, and 15 g arginine once daily 14 days pre-operatively and post-operatively. Both groups receive high quality protein (1.5 g protein/kg body weight) daily during the same period. Hernia repair is done using the Lichtenstein technique. Drainage tubes are placed in the wound during the surgery. Epidermal wounds (10 mm) are made via the suction blister method on the ventral forearm of the patients on the day of surgery. Blood samples are drawn at day -14, day 0, day 1 and day 2. The surgical drain is emptied and fluid collected at day 1 and day 2.The healing of the suction blisters is assessed by clinical criteria until healing.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Control
Total daily protein intake: 1.5 g protein/kg body weight
Control
High quality protein supplement 14 days pre-operatively and post-operatively.
Intervention
55 mg zinc/day, 1251 mg vitamin C/day, and 15 g arginine/day. Total daily protein intake: 1.5 g protein/kg body weight
Intervention
The patients in the intervention group are given 55 mg zinc, 1251 mg vitamin C, and 15 g arginine once daily 14 days pre-operatively and post-operatively together with a high quality protein supplement.
Interventions
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Intervention
The patients in the intervention group are given 55 mg zinc, 1251 mg vitamin C, and 15 g arginine once daily 14 days pre-operatively and post-operatively together with a high quality protein supplement.
Control
High quality protein supplement 14 days pre-operatively and post-operatively.
Eligibility Criteria
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Inclusion Criteria
* Patients undergoing hernia repair using the Lichtenstein technique
* Written informed consent
Exclusion Criteria
* Dementia
* Dysregulated diabetes
* Systemic corticosteroid treatment
* Liver disease
* Kidney disease
* Cancer within 5 years
* Need of interpreter
18 Years
MALE
No
Sponsors
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Lars Nannestad Jorgensen
OTHER
Responsible Party
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Lars Nannestad Jorgensen
Professor, MD, DrMedSci
Principal Investigators
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Lars N Joergensen
Role: PRINCIPAL_INVESTIGATOR
K. Forskning, BIspebjerg Hospital
Locations
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Bispebjerg Hospital
Copenhagen, Copenhagen NV, Denmark
Countries
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References
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Kjaer M, Frederiksen AKS, Nissen NI, Willumsen N, van Hall G, Jorgensen LN, Andersen JR, Agren MS. Multinutrient Supplementation Increases Collagen Synthesis during Early Wound Repair in a Randomized Controlled Trial in Patients with Inguinal Hernia. J Nutr. 2020 Apr 1;150(4):792-799. doi: 10.1093/jn/nxz324.
Other Identifiers
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H-15017272
Identifier Type: -
Identifier Source: org_study_id
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