Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

NCT ID: NCT04533204

Last Updated: 2021-03-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 59 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-08-01
• Study Completion Date: 2014-07-30

Brief Summary

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Detailed Description

Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the "trained" stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.

Conditions

Mild Cognitive Impairment

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Mnemonic strategy training

Training using mnemonic strategies

Group Type: EXPERIMENTAL

mnemonic strategy training

Intervention Type: BEHAVIORAL

training using mnemonic strategies

Spaced retrieval training

Training using spaced retrieval

Group Type: ACTIVE_COMPARATOR

spaced retrieval training

Intervention Type: BEHAVIORAL

training using spaced retrieval

Interventions

mnemonic strategy training

training using mnemonic strategies

Intervention Type: BEHAVIORAL

spaced retrieval training

training using spaced retrieval

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

-Diagnosis of MCI according to Petersen (2004) criteria, right handed

Exclusion Criteria

• Diagnosis of other neurological condition,
• active drug/alcohol abuse/dependence,
• moderate-severe depression or other Axis I diagnoses.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

VA Office of Research and Development

FED

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Benjamin M. Hampstead, PhD

Role: PRINCIPAL_INVESTIGATOR

VA Ann Arbor Healthcare System, Ann Arbor, MI

Locations

VA Ann Arbor Healthcare System, Ann Arbor, MI

Ann Arbor, Michigan, United States

Countries

United States

Other Identifiers

B6366-W-1

Identifier Type: -

Identifier Source: org_study_id