Memory Training and Neural Plasticity

NCT ID: NCT05380739

Last Updated: 2025-10-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-07

Study Completion Date

2023-05-11

Brief Summary

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This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).

Detailed Description

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Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).

Conditions

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Mild Cognitive Impairment

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Participants in the MCI group will be assigned to receive either in-person (Arm1) or online WM training (Arm2), based on their preference and availability of equipment ensuring a stable internet connection, for 10 training sessions. Participants in the HC group will receive online training (Arm3). Data for HC who received in-person training was already collected (HUM00033133). WM performance in conjunction with brain imaging will be assessed within-subject, twice pre-training (Time1 and Time2) and once post-training (Time3), as well as \~1 month after training (Follow-up). The Time1 vs. Time2 comparison will reveal task-exposure effects, whereas the Time2 vs. Time3 comparison will reveal training effects.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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In-Person, MCI

Participants diagnosed with MCI will undergo 10 sessions of WM training in person.

Group Type ACTIVE_COMPARATOR

Working Memory Training

Intervention Type BEHAVIORAL

A 10-session working memory (WM) training program

Online, MCI

Participants diagnosed with MCI will undergo 10 sessions of WM training online.

Group Type ACTIVE_COMPARATOR

Working Memory Training

Intervention Type BEHAVIORAL

A 10-session working memory (WM) training program

Online, Healthy

Cognitively intact older adults will undergo 10 sessions of WM training online.

Group Type ACTIVE_COMPARATOR

Working Memory Training

Intervention Type BEHAVIORAL

A 10-session working memory (WM) training program

Interventions

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Working Memory Training

A 10-session working memory (WM) training program

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* MCI Diagnosis
* Right-handedness
* MRI-eligibility for MRI participants

Exclusion Criteria

* History of other contributing neurological or medical conditions known to affect cognitive functioning
* Significant mental illness
* Sensory impairments that limit ability to participate
* History of alcohol or drug abuse/dependence
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Alexandru Iordan

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alexandru Iordan, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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HUM00199574

Identifier Type: -

Identifier Source: org_study_id

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