The Neural Substrates for Working Memory Training

NCT ID: NCT03012269

Last Updated: 2017-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Brief Summary

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This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.

Detailed Description

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Conditions

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Rehabilitation Working Memory

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Working Memory Training

The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.

Group Type EXPERIMENTAL

Working memory training

Intervention Type BEHAVIORAL

Non-Working Memory Training

The subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Working memory training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Right handedness
* Diagnosis of traumatic brain injury or stroke
* Course of disease within one year
* The score of MoCA test \> 24
* Able to understand instructions

Exclusion Criteria

* Aphasia, unilateral spatial neglect, agnosia, apraxia
* Hearing impairment or visual impairment
* History of taking psychiatric drugs
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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China Rehabilitation Research Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Yun XiaoPing

Director of Department of Rehabilitation Evaluation

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xiaoping Yun, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Rehabilitation Evaluation, China Rehabilitation Research Center

Locations

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Department of Rehabilitation Evaluation, China Rehabilitation Research Center

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiaoping Yun, MD

Role: CONTACT

86-01067574465

Facility Contacts

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Xiaoping Yun, MD

Role: primary

8601067574465

Other Identifiers

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NSFC-81272165

Identifier Type: -

Identifier Source: org_study_id

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