PC-Based Cognitive Rehabilitation for Traumatic Brain Injury (TBI)
NCT ID: NCT00927576
Last Updated: 2015-07-31
Study Results
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View full resultsBasic Information
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COMPLETED
265 participants
OBSERVATIONAL
2009-07-31
2013-03-31
Brief Summary
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Note: the original design of the study was altered due to failure to recruit sufficient numbers of patients who were willing to undergo prolonged cognitive training.
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Detailed Description
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Normative data were obtained by regressing the influences of age, education, and computer use on scores to create normed z-scores on different NPTs,. We hypothesized that patient with TBI would show deficits on tests of memory, attention, and executive function relative to their predicted z-scores (based on the aforementioned regression functions) and that deficits would be more pronounced in patients with severe TBI than in patients with mild TBI.
Conditions
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Study Design
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ECOLOGIC_OR_COMMUNITY
CROSS_SECTIONAL
Study Groups
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Control subjects
Control subjects = 237. These subjects underwent extensive testing with computerized neuropsychological tests including digit span testing, spatial span testing, simple reaction time testing, choice reaction time testing, finger tapping, verbal fluency, design fluency, verbal list learning, questionnaire completion, and the trail making test.
Digit span testing
Testing of short-term verbal memory with digit span
Spatial span testing
Testing of short-term visuospatial memory with spatial span.
Finger tapping
Testing motor speed with a finger tapping test.
Simple reaction time
Testing the time to respond to the appearance of a visual stimulus.
Choice reaction time
Testing the time needed to discriminate and respond to different visual stimuli.
Verbal fluency
Evaluating how many words are produced in 90s.
Verbal list learning
Evaluating short-term memory, learning, and memory interference in the recall of 12-word lists, presented three times. Evaluating long-term memory and recognition after a 20 min interval.
Trail making test
Evaluating visuomotor speed and executive function in Trail Making Tests, A and B. In the first, subjects connect successive numbers with the mouse. In the second, they connect numbers and letters in alternation.
Design fluency
Subjects create the maximal number of 4-line patterns in 90 s.
Questionnaire completion
Question completion time is measured on each question of the Post-Traumatic Stress Disorder check list (PCL) and on the cognitive failures questionnaire.
TBI patients
TBI patients N = 28. These patients underwent extensive testing with computerized neuropsychological tests including digit span testing, spatial span testing, simple reaction time testing, choice reaction time testing, finger tapping, verbal fluency, design fluency, verbal list learning, questionnaire completion, and the trail making test.
Digit span testing
Testing of short-term verbal memory with digit span
Spatial span testing
Testing of short-term visuospatial memory with spatial span.
Finger tapping
Testing motor speed with a finger tapping test.
Simple reaction time
Testing the time to respond to the appearance of a visual stimulus.
Choice reaction time
Testing the time needed to discriminate and respond to different visual stimuli.
Verbal fluency
Evaluating how many words are produced in 90s.
Verbal list learning
Evaluating short-term memory, learning, and memory interference in the recall of 12-word lists, presented three times. Evaluating long-term memory and recognition after a 20 min interval.
Trail making test
Evaluating visuomotor speed and executive function in Trail Making Tests, A and B. In the first, subjects connect successive numbers with the mouse. In the second, they connect numbers and letters in alternation.
Design fluency
Subjects create the maximal number of 4-line patterns in 90 s.
Questionnaire completion
Question completion time is measured on each question of the Post-Traumatic Stress Disorder check list (PCL) and on the cognitive failures questionnaire.
Interventions
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Digit span testing
Testing of short-term verbal memory with digit span
Spatial span testing
Testing of short-term visuospatial memory with spatial span.
Finger tapping
Testing motor speed with a finger tapping test.
Simple reaction time
Testing the time to respond to the appearance of a visual stimulus.
Choice reaction time
Testing the time needed to discriminate and respond to different visual stimuli.
Verbal fluency
Evaluating how many words are produced in 90s.
Verbal list learning
Evaluating short-term memory, learning, and memory interference in the recall of 12-word lists, presented three times. Evaluating long-term memory and recognition after a 20 min interval.
Trail making test
Evaluating visuomotor speed and executive function in Trail Making Tests, A and B. In the first, subjects connect successive numbers with the mouse. In the second, they connect numbers and letters in alternation.
Design fluency
Subjects create the maximal number of 4-line patterns in 90 s.
Questionnaire completion
Question completion time is measured on each question of the Post-Traumatic Stress Disorder check list (PCL) and on the cognitive failures questionnaire.
Eligibility Criteria
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Inclusion Criteria
* (b) no current or prior history of bipolar disorder, mania, or schizophrenia
* (c) no current substance abuse
* (d) no concurrent history of neurologic disease known to affect cognitive functioning
* (e) on a stable dosage of any required medication
* (f) auditory functioning sufficient to understanding normal conversational speech and visual acuity normal or corrected to 20/40 or better
Exclusion Criteria
* current substance abuse
* current psychiatric diagnosis other than PTSD
18 Years
78 Years
ALL
Yes
Sponsors
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US Department of Veterans Affairs
FED
Responsible Party
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Principal Investigators
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David L. Woods, PhD
Role: PRINCIPAL_INVESTIGATOR
VA Northern California HCS
References
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Atkins Whitmer D, Woods DL. Analysis of the cost effectiveness of a suicide barrier on the Golden Gate Bridge. Crisis. 2013;34(2):98-106. doi: 10.1027/0227-5910/a000179.
Disbrow EA, Russo KA, Higginson CI, Yund EW, Ventura MI, Zhang L, Malhado-Chang N, Woods DL, Sigvardt KA. Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease. Brain Res. 2012 May 3;1452:151-64. doi: 10.1016/j.brainres.2012.02.073. Epub 2012 Mar 9.
Whitaker KJ, Kang X, Herron TJ, Woods DL, Robertson LC, Alvarez BD. White matter microstructure throughout the brain correlates with visual imagery in grapheme-color synesthesia. Neuroimage. 2014 Apr 15;90:52-9. doi: 10.1016/j.neuroimage.2013.12.054. Epub 2014 Jan 7.
Woods DL, Herron TJ, Yund EW, Hink RF, Kishiyama MM, Reed B. Computerized analysis of error patterns in digit span recall. J Clin Exp Neuropsychol. 2011 Aug;33(7):721-34. doi: 10.1080/13803395.2010.550602.
Hubel KA, Reed B, Yund EW, Herron TJ, Woods DL. Computerized measures of finger tapping: effects of hand dominance, age, and sex. Percept Mot Skills. 2013 Jun;116(3):929-52. doi: 10.2466/25.29.PMS.116.3.929-952.
Hubel KA, Yund EW, Herron TJ, Woods DL. Computerized measures of finger tapping: reliability, malingering and traumatic brain injury. J Clin Exp Neuropsychol. 2013;35(7):745-58. doi: 10.1080/13803395.2013.824070. Epub 2013 Aug 15.
Woods DL, Kishiyamaa MM, Lund EW, Herron TJ, Edwards B, Poliva O, Hink RF, Reed B. Improving digit span assessment of short-term verbal memory. J Clin Exp Neuropsychol. 2011 Jan;33(1):101-11. doi: 10.1080/13803395.2010.493149.
Other Identifiers
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B6119-R
Identifier Type: -
Identifier Source: org_study_id
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