Cognitive Training and Practice Effects in Mild Cognitive Impairment

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

197 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2020-02-28

Brief Summary

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The current study will test the effectiveness of a computerized cognitive training program on auditory memory and attention in patients with mild cognitive impairment. Practice effects will also be examined as a moderator of treatment response.

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Detailed Description

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The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.

Conditions

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Mild Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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experimental cognitive training

Participants will use experimental computerized cognitive training exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks.

Group Type EXPERIMENTAL

computerized cognitive exercises

Intervention Type BEHAVIORAL

Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.

control cognitive exercises

Participants will use control computerized cognitive activities, 1 hour per day, 3 - 5 days per week, for 13 weeks.

Group Type ACTIVE_COMPARATOR

computerized cognitive exercises

Intervention Type BEHAVIORAL

Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.

Interventions

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computerized cognitive exercises

Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Mild Cognitive Impairment, amnestic subtype

* 65 years of age or older
* Availability of a knowledgeable informant
* Access to internet 3 hours per week
* Adequate vision, hearing, and motor responding to participate in training

Exclusion Criteria

* History of major stroke, head injury with loss of consciousness of \>30 minutes, or other neurological disorder or systemic illness that are thought to be affecting cognition (e.g., seizure disorder, demyelinating disorder, etc.)
* Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder)
* History of substance abuse
* Current use of antipsychotics or anticonvulsant medications
* Currently residing in a nursing home or other skilled nursing facility

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No