Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
NCT ID: NCT00643266
Last Updated: 2018-11-16
Study Results
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Basic Information
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COMPLETED
NA
91 participants
INTERVENTIONAL
2008-02-29
2013-08-31
Brief Summary
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Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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1
Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days
Recollection Training
Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.
2
Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants
Control
Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain
Interventions
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Recollection Training
Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.
Control
Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* English as a first language or learned before kindergarten
* Right handed
Exclusion Criteria
* Major medical disorder affecting cognition
* Psychiatric disorder
* Metal in the body that poses a hazard in the MRI scanner
65 Years
90 Years
ALL
Yes
Sponsors
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Baycrest
OTHER
Responsible Party
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Dr. Nicole D. Anderson
Senior Scientist
Principal Investigators
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Nicole D Anderson, PhD, CPsych
Role: PRINCIPAL_INVESTIGATOR
Baycrest
Locations
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Baycrest
Toronto, Ontario, Canada
Countries
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References
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Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008 Mar;22(2):177-87. doi: 10.1037/0894-4105.22.2.177.
Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND. Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2014;36(7):751-60. doi: 10.1080/13803395.2014.941790. Epub 2014 Aug 30.
Ebert PL, Anderson ND. Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan;15(1):83-93. doi: 10.1017/S1355617708090115.
Anderson ND, Ebert PL, Grady CL, Jennings JM. Repetition lag training eliminates age-related recollection deficits (and gains are maintained after three months) but does not transfer: Implications for the fractionation of recollection. Psychol Aging. 2018 Feb;33(1):93-108. doi: 10.1037/pag0000214.
Meusel LA, Grady CL, Ebert PE, Anderson ND. Brain-behavior relationships in source memory: Effects of age and memory ability. Cortex. 2017 Jun;91:221-233. doi: 10.1016/j.cortex.2016.12.023. Epub 2017 Jan 12.
Other Identifiers
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CIHR MOP 67015
Identifier Type: -
Identifier Source: secondary_id
ASC 08 95
Identifier Type: -
Identifier Source: secondary_id
RecollectionTraining
Identifier Type: -
Identifier Source: org_study_id
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