Trial Outcomes & Findings for Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment (NCT NCT04533204)
NCT ID: NCT04533204
Last Updated: 2021-03-23
Results Overview
Change in memory for 45 trained object location associations
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
59 participants
Primary outcome timeframe
up to 1 month after last training session
Results posted on
2021-03-23
Participant Flow
Participant milestones
| Measure |
Mnemonic Strategy Training
Training using mnemonic strategies
mnemonic strategy training: training using mnemonic strategies
|
Spaced Retrieval Training
Training using spaced retrieval
spaced retrieval training: training using spaced retrieval
|
|---|---|---|
|
Overall Study
STARTED
|
29
|
30
|
|
Overall Study
COMPLETED
|
28
|
29
|
|
Overall Study
NOT COMPLETED
|
1
|
1
|
Reasons for withdrawal
| Measure |
Mnemonic Strategy Training
Training using mnemonic strategies
mnemonic strategy training: training using mnemonic strategies
|
Spaced Retrieval Training
Training using spaced retrieval
spaced retrieval training: training using spaced retrieval
|
|---|---|---|
|
Overall Study
Unable to understand training instructions
|
1
|
1
|
Baseline Characteristics
1 participant in each group was removed due to inability to understand training instructions
Baseline characteristics by cohort
| Measure |
Mnemonic Strategy Training
n=28 Participants
Training using mnemonic strategies
mnemonic strategy training: training using mnemonic strategies
|
Spaced Retrieval Training
n=29 Participants
Training using spaced retrieval
spaced retrieval training: training using spaced retrieval
|
Total
n=57 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=5 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
0 Participants
n=7 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
0 Participants
n=5 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
|
Age, Categorical
Between 18 and 65 years
|
5 Participants
n=5 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
7 Participants
n=7 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
12 Participants
n=5 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
|
Age, Categorical
>=65 years
|
23 Participants
n=5 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
22 Participants
n=7 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
45 Participants
n=5 Participants • 1 participant in each group was removed due to inability to understand training instructions
|
|
Age, Continuous
|
72.7 Years
STANDARD_DEVIATION 8.3 • n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
70.5 Years
STANDARD_DEVIATION 8.3 • n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
71.6 Years
STANDARD_DEVIATION 8.3 • n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Sex: Female, Male
Female
|
10 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
14 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
24 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Sex: Female, Male
Male
|
18 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
15 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
33 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
Black or African American
|
8 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
11 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
19 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
White
|
19 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
17 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
36 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
0 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
1 Participants
n=7 Participants • 1 participant in each group removed due to inability to understand training instructions
|
2 Participants
n=5 Participants • 1 participant in each group removed due to inability to understand training instructions
|
|
Region of Enrollment
United States
|
28 Participants
n=5 Participants
|
29 Participants
n=7 Participants
|
57 Participants
n=5 Participants
|
PRIMARY outcome
Timeframe: up to 1 month after last training sessionChange in memory for 45 trained object location associations
Outcome measures
| Measure |
Mnemonic Strategy Training
n=28 Participants
Training using mnemonic strategies
mnemonic strategy training: training using mnemonic strategies
|
Spaced Retrieval Training
n=29 Participants
Training using spaced retrieval
spaced retrieval training: training using spaced retrieval
|
|---|---|---|
|
Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment
|
80.0 percent correct
Interval 74.86 to 85.14
|
62.45 percent correct
Interval 57.4 to 67.51
|
SECONDARY outcome
Timeframe: up to 1 month after last training sessionPopulation: Computer errors resulted in loss of data from the first 15 participants (7 MST, 8 SRT)
Change in accuracy for novel object location associations using a touchscreen task; distance measured in cm from actual location
Outcome measures
| Measure |
Mnemonic Strategy Training
n=21 Participants
Training using mnemonic strategies
mnemonic strategy training: training using mnemonic strategies
|
Spaced Retrieval Training
n=21 Participants
Training using spaced retrieval
spaced retrieval training: training using spaced retrieval
|
|---|---|---|
|
Change in Accuracy (vs. Baseline) on Novel Object Location Associations
|
6.1 error in centimeters
Interval 4.8 to 7.4
|
7.14 error in centimeters
Interval 5.84 to 8.44
|
Adverse Events
Mnemonic Strategy Training
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Spaced Retrieval Training
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Benjamin Hampstead
VA Ann Arbor Healthcare System; University of Michigan
Phone: 734-763-9259
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place