Muscle Response to High Intensity Interval Resistance Training (HIIRT)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-01

Study Completion Date

2013-02-10

Brief Summary

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Resistance training (RT) is one of the most important stimuli for muscle hypertrophy and it plays an important role on weight loss and fatty acid oxidation increase. RT affects anabolic pathways but the differences among various training techniques has been till now were poorly investigated. The aim of this study was to compare the effect of two different intensity of training, high-intensity interval resistance training (HIIRT) and traditional resistance training (TRT), on muscle signalling pathway.

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Detailed Description

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Nine young healthy subjects performed HIIRT and TRT protocol in two different moments and with different legs. HIIRT technique consisted of three sets of: 6 repetitions at 6RM (6 repetitions maximum) and then 20 seconds of rest and 2/3 repetitions (until exhaustion) repeated for 3 times with 2'30" rest between sets; while TRT consisted of 3 sets of 15 reps with 75 sec of rest between sets. Biopsies from the vastus lateralis were taken at baseline (pre), immediately (0h) at the end of training, 6 hours (6h) and 24 hours (24h) after training. Western blot and RT-PCR mRNA (Reverse transcriptase-polymerase chain reaction) analysis were performed to assess muscle signalling pathway activation

Conditions

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Exercise Resistance Training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Same subjects serve as both the test and control arms which allows for within-subject comparison. Using a within-person design, participants trained each lower limb on separate days under two different training stimulus (HIIRT) and traditional training (TRT)

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

The samples analysed were masked by a number without any indication of the arm.

Study Groups

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High Intensity Interval Resistance Training (HIIRT)

HIIRT technique consisted of three sets of: 6 repetitions at 80% 1RM (1 repetition maximum) and then 20 seconds of rest and 2/3 repetitions (until exhaustion) repeated for 3 times with 2'30" rest between sets; while TRT consisted of 3 sets of 15 reps with 75 sec of rest between sets.

Group Type EXPERIMENTAL

High Intensity Interval Resistance Training

Intervention Type OTHER

Subjects trained one leg with HIIRT

Traditional Resistance Training (TRT)

TRT protocol performed 3 series of 15 repetitions at 60% 1RM with 75" of rest between sets.

Group Type ACTIVE_COMPARATOR

Traditional Resistance Training

Intervention Type OTHER

Subjects trained the other leg with HIIRT

Interventions

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High Intensity Interval Resistance Training

Subjects trained one leg with HIIRT

Intervention Type OTHER

Traditional Resistance Training

Subjects trained the other leg with HIIRT

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* moderate active
* experience with resistance training

Exclusion Criteria

* history of recent myocardial infarction,
* severe cardiac arrhythmia,
* unstable angina,
* poorly controlled hypertension,
* poorly controlled diabetes mellitus,
* frequent or complex ventricular ectopy which might interfere with one's ability to adhere to exercise protocols

Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes