Individual Response to Different Volumes of Resistance Training

NCT ID: NCT02179307

Last Updated: 2015-11-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-08-31
• Study Completion Date: 2015-04-30

Brief Summary

The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.

The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.

Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.

The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.

Conditions

Healthy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Arm label 1-Set, 3-Set

12-week progressive strength training protocol of different volumes

Group Type: EXPERIMENTAL

12-week progressive strength training protocol

Intervention Type: BEHAVIORAL

Every study participant will complete 12 weeks of progressive strength training with one leg performing 1-set per exercise per session and the contralateral leg performing 3-sets per exercise per session. Allocation of dominant/non-dominant leg to either 1- or 3-set protocol will be done in a stratified, randomized fashion (stratified with regard to sex and baseline strength).

Interventions

12-week progressive strength training protocol

Every study participant will complete 12 weeks of progressive strength training with one leg performing 1-set per exercise per session and the contralateral leg performing 3-sets per exercise per session. Allocation of dominant/non-dominant leg to either 1- or 3-set protocol will be done in a stratified, randomized fashion (stratified with regard to sex and baseline strength).

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy
• Non-smoking
• Able to tolerate resistance exercise training

Exclusion Criteria

• Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
• Diagnosed mental health disorder
• Intolerance to local anesthetic
• No experience with exercise training
• Performing regular resistance training (more than 1 session per week during last 12 months)
• Impaired strength/ neuromuscular function due to previous injury
• Recurrent pain in lower back, knee or shoulders
• Taking prescribed medication that may affect outcome of training intervention

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sykehuset Innlandet HF

OTHER

Sponsor Role: collaborator

Revmatismesykehuset AS

OTHER

Sponsor Role: collaborator

Inland Norway University of Applied Sciences

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Stian Ellefsen, PhD

Role: PRINCIPAL_INVESTIGATOR

Inland Norway University of Applied Sciences

Locations

Lillehammer University College

Lillehammer, , Norway

Countries

Norway

Other Identifiers

Trainsome 2014#002

Identifier Type: -

Identifier Source: org_study_id