Muscle Typology and Strength Training Adaptations

NCT ID: NCT05108181

Last Updated: 2024-04-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-09-09
• Study Completion Date: 2023-12-08

Brief Summary

The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.

Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).

Conditions

Muscle Fiber Type; Exercise; Training Frequency

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Slow muscle typology group

The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.

Group Type: ACTIVE_COMPARATOR

Muscle typology + exercise training

Intervention Type: OTHER

Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.

Muscle typology + training frequency

Intervention Type: OTHER

Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Fast muscle typology group

The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.

Group Type: ACTIVE_COMPARATOR

Muscle typology + exercise training

Intervention Type: OTHER

Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.

Muscle typology + training frequency

Intervention Type: OTHER

Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Interventions

Muscle typology + exercise training

Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.

Intervention Type: OTHER

Muscle typology + training frequency

Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Fast or slow muscle typology
• 18 - 45 years old
• no strength training experience

Exclusion Criteria

• Vegan/vegeterian diet
• Supplement intake
• chronic diseases
• Hypertension,
• Smoking
• Medication use
• Coagulation disorder, infectious diseases

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Ghent

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Wim Derave

Role: PRINCIPAL_INVESTIGATOR

University Ghent

Locations

Department of Movement and Sports Sciences, Ghent University

Ghent, Oost-Vlaanderen, Belgium

Countries

Belgium

Other Identifiers

BC-10253

Identifier Type: -

Identifier Source: org_study_id