Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

NCT ID: NCT04228510

Last Updated: 2020-01-14

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 204 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-03-31
• Study Completion Date: 2021-12-31

Brief Summary

ST-segment elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality worldwide. In spite of decrease in acute and long-term mortality following STEMI in parallel with more use of reperfusion therapy, such as primary percutaneous coronary intervention (PPCI), modern antithrombotic therapy, and secondary prevention, mortality remains considerable. Reduced EF is a well-known predictor of increased short and long term major adverse cardiovascular events MACE :( heart failure, stroke and death)

Conditions

Myocardial Infarction

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Study group

ST elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention who will be followed up in Assiut University hospital.

2D speckle tracking echocardiography

Intervention Type: PROCEDURE

Global and segmental strain and strain rate in longitudinal and circumferential directions will be detected after PPCI; before discharge. The LV circumferential strains and strain rates will be determined from the short-axis views at the basal, middle, and apical levels, and longitudinal strains and strain rates will be determined from the apical 2-, 3-, and 4-chamber views of the LV.

Segmental longitudinal strains equal to -15% or closer to 0 will be considered abnormal (injured segments). The average segmental longitudinal strain and strain rate of the abnormal segments is defined as the injury longitudinal strain (InjLS) and injury longitudinal systolic strain rate (InjLSRs).

Interventions

2D speckle tracking echocardiography

Global and segmental strain and strain rate in longitudinal and circumferential directions will be detected after PPCI; before discharge. The LV circumferential strains and strain rates will be determined from the short-axis views at the basal, middle, and apical levels, and longitudinal strains and strain rates will be determined from the apical 2-, 3-, and 4-chamber views of the LV.

Segmental longitudinal strains equal to -15% or closer to 0 will be considered abnormal (injured segments). The average segmental longitudinal strain and strain rate of the abnormal segments is defined as the injury longitudinal strain (InjLS) and injury longitudinal systolic strain rate (InjLSRs).

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• ST elevation myocardial infarction patients after primary percutaneous coronary intervention

Exclusion Criteria

• Previous myocardial infarction.
• Sever or haemodynamically significant (associated with chamber dilation) valvular heart diseases.
• Previous heart failure.
• Previous cerebrovascular strokes.
• Atrial fibrillation.
• Severe comorbidities as severe renal impairment, hepatic or respiratory failure.
• Bad equality views which affects accurate speckle tracking imaging.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Waleed Rafat Rasmy

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hatem Helmy, MD

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

Aly Tohamy, MD

Role: CONTACT

Ali.tohamy@gmail.com

01006258877

Ayman Khairy, MD

Role: CONTACT

Aymankhairy11@gmail.com

01094438055

Other Identifiers

2DSE

Identifier Type: -

Identifier Source: org_study_id