Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study

NCT ID: NCT06860997

Last Updated: 2025-03-06

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-12
• Study Completion Date: 2026-03-31

Brief Summary

The goal of this prospective observational study is to assess the diagnostic accuracy of the tissue Doppler imaging (TDI) S' wave in detecting acute coronary syndrome (ACS) in adult patients presenting to the emergency department (ED) with acute chest pain. This study focuses on patients aged 18 years or older, who require continuous cardiac monitoring but do not show ST-elevation myocardial infarction (STEMI) on their initial ECG.

The main questions it aims to answer are:

• Can TDI S' wave velocity serve as an early diagnostic marker for ACS in the emergency department?
• How does the diagnostic performance of TDI S' compare with other echocardiographic markers (MAPSE, TAPSE, and diastolic parameters such as E, E', A, E/A, E/E')?
• Do demographic factors (age, sex, BMI, echogenicity) influence the diagnostic accuracy of echocardiographic parameters for ACS? If there is a comparison group: Researchers will compare TDI S' wave velocity findings with the final adjudicated diagnosis of ACS (determined after 3 months) to evaluate its sensitivity and specificity.

Conditions

Acute Coronary Syndrome; Myocardial Infarction (MI); Non-ST Elevation Myocardial Infarction; Unstable Angina; Echocardiography; Tissue Doppler; Emergency Medicine; Cardiac Function Tests

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Echocardiographic Assessment for Early ACS Detection

This arm involves bedside echocardiographic assessment using tissue Doppler imaging (TDI) S' wave velocity to evaluate its diagnostic accuracy for acute coronary syndrome (ACS) in patients presenting with acute chest pain in the emergency department (ED).

Group Type: OTHER

Tissue Doppler Imaging (TDI) S' Wave Echocardiography

Intervention Type: DIAGNOSTIC_TEST

This intervention involves bedside echocardiographic assessment using TDI S' wave velocity to evaluate its diagnostic accuracy for acute coronary syndrome (ACS) in patients presenting with acute chest pain in the emergency department (ED).

Interventions

Tissue Doppler Imaging (TDI) S' Wave Echocardiography

This intervention involves bedside echocardiographic assessment using TDI S' wave velocity to evaluate its diagnostic accuracy for acute coronary syndrome (ACS) in patients presenting with acute chest pain in the emergency department (ED).

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Age ≥18 years
• Presenting to the emergency department (ED) with acute chest pain
• No ST-elevation myocardial infarction (STEMI) on initial ECG
• Requiring continuous cardiac monitoring based on triage decision
• Able to provide informed consent (written consent required)

Exclusion Criteria

• Known pre-existing cardiomyopathy (e.g., hypertrophic cardiomyopathy, dilated cardiomyopathy)
• Severe valvular heart disease
• Left bundle branch block (LBBB) or presence of a pacemaker
• Arrhythmias (e.g., atrial fibrillation, frequent premature ventricular contractions)
• Cardiac arrest or cardiogenic shock at presentation
• Pulmonary hypertension
• Pericardial effusion or tamponade
• Non-cardiac cause of chest pain suspected as the primary diagnosis
• Language barrier preventing informed consent (study materials available in English, French, and Dutch)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bastian Rodrigues de Castro, MD

Role: PRINCIPAL_INVESTIGATOR

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Locations

Cliniques Universitaires Saint-Luc

Brussels, , Belgium

Site Status: RECRUITING

Countries

Belgium

Central Contacts

Bastian Rodrigues de Castro, MD

Role: CONTACT

bastian.rodrigues@saintluc.uclouvain.be

+32498236523

Facility Contacts

Bastian Rodrigues de Castro, Doctor

Role: primary

bastian.rodrigues@saintluc.uclouvain.be

+32 498 23 65 23

Lara Absil, PhD

Role: backup

lara.absil@saintluc.uclouvain.be

+32 2 764 86 45

Other Identifiers

2024/28OCT/476

Identifier Type: -

Identifier Source: org_study_id