Detection of Ultrasound Contrast Signals in the Cerebral Circulation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2006-04-27

Study Completion Date

2009-12-12

Brief Summary

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To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.

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Detailed Description

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The purpose of this study is to determine whether the intravenous microbubbles used to improve border delineation during dobutamine stress echocardiographies (DSE) can be detected within the cerebral circulation.

Conditions

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Brain Vascular Disorders Coronary Artery Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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1 Transcranial imaging using Doppler Ultrasound

Transcranial imaging using Doppler ultrasound

Group Type EXPERIMENTAL

Ultrasound on Temporal Bone

Intervention Type PROCEDURE

All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.

Interventions

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Ultrasound on Temporal Bone

All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* male or female age \>19 years of age
* scheduled for a stress echocardiogram
* negative urine pregnancy test within two hours of ultrasound contrast administration required for females of childbearing age unless post-menopausal or with evidence of surgical sterilization
* be conscious and coherent, and able to communicate effectively with trial personnel

Exclusion Criteria

* pregnant or lactation
* life expectancy of less than 2 months or terminally ill
* Known or suspected hypersensitivity to ultrasound contrast agent used for the study
* complicated hemodynamic instability
* Known left main disease

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes