Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2017-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether stress echocardiography or computed tomography (CT) of the heart is better at diagnosing emergency room chest pain patients to select appropriate candidates for hospitalization and further work-up.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Use of Echocardiography in the Evaluation of Chest Pain in the Emergency Department

NCT01125072

Chest Pain

WITHDRAWN

Study of Coronary Artery Computed Tomography to Diagnose Emergency Chest Pain

NCT00273832

Chest Pain Angina Pectoris Myocardial Infarction

COMPLETED PHASE2

Coronary Computed Tomographic Angiography in Intermediate-risk Chest Pain Patients

NCT04748237

Chest Pain Acute Coronary Syndrome Coronary Artery Disease

RECRUITING NA

Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain

NCT00705458

Coronary Artery Disease Angina Pectoris Unstable Angina +1 more

COMPLETED NA

Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome

NCT00473863

Acute Coronary Syndrome Acute Myocardial Infarction Unstable Angina +2 more

UNKNOWN PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chest Pain Angina Angina Pectoris Coronary Artery Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Initial Stress Echocardiography

Group Type EXPERIMENTAL

Stress Echocardiography

Intervention Type PROCEDURE

Stress echocardiography will be performed once. Treadmill stress is default. Patients that cannot exercise will receive dobutamine stress with or without atropine. Definity intravenous contrast will be given when needed.

Initial Coronary CT Angiography

Group Type EXPERIMENTAL

Coronary CT Angiography

Intervention Type PROCEDURE

64-detector, resting EKG-gated coronary CT angiography will be performed once. Patients with elevated heart rates will be given oral and/or intravenous metoprolol. Prospective gating with reduced tube current will be default. Retrospective gating with tube current modulation will be used in patients with higher heart rates.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Stress Echocardiography

Stress echocardiography will be performed once. Treadmill stress is default. Patients that cannot exercise will receive dobutamine stress with or without atropine. Definity intravenous contrast will be given when needed.

Intervention Type PROCEDURE

Coronary CT Angiography

64-detector, resting EKG-gated coronary CT angiography will be performed once. Patients with elevated heart rates will be given oral and/or intravenous metoprolol. Prospective gating with reduced tube current will be default. Retrospective gating with tube current modulation will be used in patients with higher heart rates.

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

stress echo treadmill stress echocardiography treadmill stress echo exercise stress echocardiography exercise stress echo dobutamine stress echocardiography dobutamine stress echo ESE TSE DSE SE Cardiac CT Cardiac CTA Coronary CT Coronary CTA Coronary Artery CT Coronary Artery CTA CT Angiography of the Coronary Arteries Computed Tomography Angiography of the Coronary Arteries CTA CCT CCTA

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Presentation to the Emergency Department with chest pain
* Low-to-intermediate risk of coronary disease per Diamond-Forrester criteria
* Free of known coronary artery disease

Exclusion Criteria

* Inability to undergo both stress echo or coronary CT for any reason
* Contraindication to intravenous iodinated contrast
* Dysrhythmia precluding EKG gating
* Heart rate greater than 60 with contraindication to beta blockers
* Administration of beta blockers within the last 12 hours
* Known severe cardiac valvular disease or pulmonary hypertension
* Stress echocardiography, coronary CT or catheterization within the last 6 months

Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No