ProspEctive First Evaluation in Chest Pain Trial

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

411 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2015-12-31

Brief Summary

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The purpose of this study is to determine the best initial test in patients admitted to the hospital complaining of chest pain.

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Detailed Description

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Currently, physicians can either choose a stress test or a CT scan of the heart to evaluate patients admitted with with chest pain. Very little is known about which test provides the best information to physicians, positively impacts patients medical care, and decreases future hospital admissions and testing. To study this the investigators are randomizing patients admitted to our hospital with chest pain to a stress test or coronary CT angiography. The investigators will then follow these patients for a 2 year period.

Conditions

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Chest Pain Shortness of Breath Suspected Acute Coronary Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Coronary CT Angiography

Patient admitted with chest pain is randomized to CCTA for assessment.

Group Type ACTIVE_COMPARATOR

Coronary CT Angiography

Intervention Type PROCEDURE

CCTA

Stress Test

Patients admitted with chest pain are randomized to a stress test (stress SPECT or Echocardiography) for assessment.

Group Type ACTIVE_COMPARATOR

Stress Test

Intervention Type PROCEDURE

Stress Test

Interventions

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Coronary CT Angiography

CCTA

Intervention Type PROCEDURE

Stress Test

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with chest pain or SOB admitted for rule out acute coronary syndrome
* Age ≥45 years
* EKG non-diagnostic for acute coronary syndrome
* At least 1 set of negative troponin I

Exclusion Criteria

* Patient with ST elevation myocardial infarction.
* Patients with non-ST elevation myocardial infarction.
* Patients with known CAD.
* Patients with serum creatinine \> 1.5.
* Atrial fibrillation or marked irregular heart rhythm.
* Patients in whom heart rate cannot be controlled.
* Patient with allergies to iodinated contrast agents.
* Pregnant women
* Patients unable to give informed consent

Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No