Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome

NCT ID: NCT00473863

Last Updated: 2007-11-20

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE3
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-11-30
• Study Completion Date: 2008-07-31

Brief Summary

The purpose of this study is to determine whether Coronary Computed Tomographic Angiography (CCTA) will increase patient safety by decreasing the rate of missed ACS and adverse events in patients who receive standard care plus CCTA versus standard care alone. Additional goals of the study are to determine whether CCTA can safely reduce the duration of ED visits and the number and duration of hospital admissions.

Detailed Description

Justification:

Acute coronary syndrome (ACS) is the clinical manifestation of acute myocardial ischemia induced by coronary artery disease (CAD). Although most patients presenting with chest pain to the Emergency Department (ED) can be stratified into "high risk" or "low risk" chest pain algorithms, patients at "intermediate risk" are more difficult to manage. This translates into lengthy waits in the ED and repetitive investigations while 5.3% of cases of ACS are still missed and too many patients are admitted to the CCU (false positive rate of 14%). CCTA is a novel, non-invasive method for evaluating coronary artery stenosis and occlusion.

The ability to accurately diagnose or exclude ACS in patients in a rapid, non-invasive fashion has been previously lacking. If CCTA is shown to be clinically useful in risk stratification of this patient population, there is great potential for increasing patient safety, reducing ED admission times and decreasing the number and duration of CCU admission.

Objectives:

ED admission and discharge times, CCU consult and decision times and duration of CCU admission, cardiac risk factors, vital signs, laboratory results, ED disposition plan, CCTA results, coronary calcium score, index hospitalization diagnosis, investigations, revascularization rates as well as 30-day diagnosis, death, adverse event rate and subsequent investigations.

Research Method:

The study population will consist of ED chest pain patients at intermediate risk of ACS. Informed consent will be obtained for both CCTA and the 30-day follow up. Patients will be randomized into one of two diagnostic arms: standard care plus CCTA versus standard care alone. If the patient receives CCTA, the test will be interpreted by a blinded radiologist and the results provided to the ED physician and entered into the patient chart. A research nurse will collect workflow and clinical data for all enrolled patients.

Two reviewers, an ED physician and a cardiologist, blinded to the CCTA results, will independently review the index and 30 day clinical data. One of the following will be assigned: acute myocardial infarction, definite unstable angina, possible unstable angina, or no acute coronary syndrome. Alternate non-ACS diagnoses will be ascertained when applicable.

Statistical Analysis This proposal represents a pilot study to demonstrate the feasibility of identifying and recruiting patients to the trial, demonstrate the feasibility of collecting follow-up data, and provide preliminary estimates of outcome measures to help determine the sample size required for a definitive study. All analyses will be descriptive. Recruitment, crossover, follow-up, and completion rates will be determined. Estimates of diagnostic accuracy and length of stay in the ED will be determined and will be used to inform the design of the definitive study.

Conditions

Acute Coronary Syndrome; Acute Myocardial Infarction; Unstable Angina; Coronary Disease; Coronary Stenosis

Keywords

Acute coronary syndrome; Acute myocardial infarction; Unstable angina; Coronary computed tomographic angiography; Coronary Angiography; Tomography, X-Ray Computed; Tomography, Spiral Computed

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: SINGLE

Study Groups

intervention

Receives CCTA

Group Type: EXPERIMENTAL

Coronary Computed Tomographic Angiography

Intervention Type: PROCEDURE

CCTA will be performed

Control

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Coronary Computed Tomographic Angiography

CCTA will be performed

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Anterior or lateral chest pain
• 19 years of age or older
• Fixed address in British Columbia
• Available for telephone follow-up

Exclusion Criteria

• Low Risk for ACS (all of the following):
• Age < 40 years with normal ECG (T wave flattening is the only acceptable abnormality)
• No prior history of ischemic chest pain (defined as a past diagnosis of MI or angina, previously prescribed nitroglycerine or a clear history of effort related angina)
• High Risk for ACS (any of the following):
• Diagnosis consistent with ST elevation myocardial infarction
• New ST depression ≥ 0.05 mV
• Troponin > 0.1
• Patients with Killip class III or IV heart failure.
• Hemodynamic instability
• Previous enrolment in this study.
• Presence of terminal noncardiac illness.
• History of angioplasty with stenting and/or grafts.
• Presence of atrial fibrillation.
• Contraindication to administration of iodinated contrast agent.
• Contraindication to beta-blocker administration (eg, asthmatics) AND calcium channel blocker administration.
• Glomerular filtration rate less than 60 mL/min.
• Previous ECG-gated CT with calcium score >1000 Agatston Units.
• Pregnancy.
• Patients with communication difficulties.
• Patients who have a clear alternative diagnosis other than ischemic chest pain (e.g. traumatic chest pain or pneumonia).

• Minimum Eligible Age: 19 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of British Columbia

OTHER

Sponsor Role: collaborator

Vancouver General Hospital

OTHER

Sponsor Role: lead

Principal Investigators

William F Dick, MD

Role: PRINCIPAL_INVESTIGATOR

Vancouver General Hospital

John Mayo, MD

Role: STUDY_DIRECTOR

Vancouver General Hospital

Locations

VGH

Vancouver, British Columbia, Canada

Site Status: RECRUITING

Countries

Canada

Central Contacts

William F Dick, MD

Role: CONTACT

Phone: 604 875 4700

Email: william.dick@vch.ca

Facility Contacts

William Dick, MD

Role: primary

Other Identifiers

H07-00742

Identifier Type: -

Identifier Source: org_study_id