Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography

NCT ID: NCT04103008

Last Updated: 2019-09-25

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-11-01
• Study Completion Date: 2020-12-01

Brief Summary

Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily clinical practice. However, this technique has limitation related with its intra- and interobserver variability. A recent technique, 2D speckle tracking for assessing global longitudinal strain, has been introduced to reduce the variability and potentially has a higher accuracy. Speckle tracking is a method which uses two dimensions recording for measuring quantity of movement of myocardium in several segments.

Speckle-tracking echocardiography is a current noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements,

Detailed Description

Authors using 2D speckle tracking found that subclinical LV systolic dysfunction is common in patients with isolated severe mitral stenosis (MS) and is determined primarily by the hemodynamic variables of MS severity and reduced LV filling. BMV results in rapid recovery of LV systolic function in these patients through improvement in LV diastolic loading. These findings suggest that LV contractile properties in MS are modulated predominantly by LV diastolic filling rather than myocardial structural abnormality.

Conditions

Myocardial Infarction; Echocardiography 2D; Left Ventricular Dysfunction

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Group A

single coronary artery lesion

Speckle tracking echocardiography

Intervention Type: DIAGNOSTIC_TEST

assess left ventricular function on admission and after 40 days

Group B

multiple coronary artery lesions

Speckle tracking echocardiography

Intervention Type: DIAGNOSTIC_TEST

assess left ventricular function on admission and after 40 days

Interventions

Speckle tracking echocardiography

assess left ventricular function on admission and after 40 days

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

2 D echocardiography

Eligibility Criteria

Inclusion Criteria

• Patients with acute myocardial infarction eligible for PCI seen on admission and after 40 days

Exclusion Criteria

• cardiomyopathy
• cancer
• on cytostatic treatment.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Karim Mohamed Eltaher Abdelrahman Aly

Resident of Cardiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Amr A Youssef, MD

Role: STUDY_CHAIR

Professor of Cardiology

Mohamed A Abdel Hafez, MD

Role: STUDY_DIRECTOR

Associate Professor

Locations

Assiut University Hospitals

Asyut, , Egypt

Countries

Egypt

Central Contacts

Karim ME Aly

Role: CONTACT

karimeltaher294@gmail.com

01068545195 ext. 002

Aliae AR Mohamed-Hussein, MD

Role: CONTACT

aliaehussein@gmail.com

01222302352 ext. 002

Facility Contacts

Aliae Mohamed-Hussein, MD

Role: primary

aliaehussein@gmail.com

01222302352 ext. 002

References

Abdelhafez MA, Aly KME, Youssef AAA. Effect of residual myocardial ischemia on recovery of left ventricular function after primary percutaneous coronary intervention. BMC Cardiovasc Disord. 2024 Mar 19;24(1):164. doi: 10.1186/s12872-024-03777-3.

Reference Type: DERIVED

PMID: 38504186 (View on PubMed)

Other Identifiers

AssiutU2019

Identifier Type: -

Identifier Source: org_study_id