Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work

NCT ID: NCT05874752

Last Updated: 2023-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

130 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-01

Study Completion Date

2023-06-01

Brief Summary

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Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) myocardial function in symptomatic patients with coronary artery disease using the promising method.

Methods: Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography. Images were stored and imported into the software for further offline analysis of PSL-based MW. MW analysis were carried out on each patient for global and regional myocardial function assessment.

Detailed Description

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Conditions

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Noninvasive Myocardial Work Coronary Artery Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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nonsignificant coronary artery stenosis group

Exclusion criteria: ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography

Transthoracic echocardiography

Intervention Type DIAGNOSTIC_TEST

noninvasive myocardial work

significant coronary artery stenosis group

Defined as ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography

Transthoracic echocardiography

Intervention Type DIAGNOSTIC_TEST

noninvasive myocardial work

Interventions

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Transthoracic echocardiography

noninvasive myocardial work

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

\-

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yingmei Liu

Role: PRINCIPAL_INVESTIGATOR

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Locations

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Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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SYSKY-2022-029-01

Identifier Type: -

Identifier Source: org_study_id

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