The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

242 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-15

Study Completion Date

2018-12-30

Brief Summary

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The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

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Detailed Description

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A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (\<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR\>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

Conditions

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Coronary Microvascular Dysfunction Obstructive Coronary Heart Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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coronary microvascular dysfunction group

Two dimensional speckle tracking imaging

Intervention Type DIAGNOSTIC_TEST

lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging

obstructive coronary artery disease

Two dimensional speckle tracking imaging

Intervention Type DIAGNOSTIC_TEST

lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging

control group

Two dimensional speckle tracking imaging

Intervention Type DIAGNOSTIC_TEST

lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging

Interventions

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Two dimensional speckle tracking imaging

lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* age from 18-85 years

Exclusion Criteria

* patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography
* patients with acute heart failure, chronic heart failure or LVEF values less than 50%
* patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation
* patients who did not store ultrasound images or whose ultrasound images were unclear
* patients who had incomplete clinical data

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No