Acute Coronary Disease (ACS)- Strain

NCT ID: NCT02357641

Last Updated: 2015-02-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-11-30
• Study Completion Date: 2015-01-31

Brief Summary

Examination of probable distinction between cardiac or non- cardiac thoracal disorder via echocardiographic myocardial strain analysis

Detailed Description

Patients with cardiac disorder have to undergo time- consuming and expensive examinations such as laboratory of cardiac biomarkers or ischemic diagnostic. To save time and money in this observational registry the probable distinction between cardiac and non- cardiac disorder in patients with vague thoracal disorder and the probability for coronary artery disease (determined via Grace Score) is examined via echographic myocardial strain analysis in 300 patients retrospectively to establish a cut off value corresponding to acute coronary disease also to prevent coronary angiography. Therefore patients undergo echography routinely with consecutive evaluation of systolic, diastolic and strain analysis to elevate exact statements with reference to deformation of the myocard and its velocity. Several study have shown that these strain parameters (circumferential and radial strain) enable vitality and ischemic diagnosis and therefore could be eligible for this purpose.

Conditions

Cardiac and Non Cardiac Thoracal Disorder

Study Design

• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with thoracal disorder

300 patients with thoracal disorder, cardiac or non- cardiac, are enrolled prospectively to undergo routinely examinations such as clinical and hemodynamic chemistry as well as echocardiography for strain analysis refering to myocardial deformation.

Especially analysis of strain data (circumferential and radial), regional and global left and right ventricular wall movement data and diastolic parameters will be analysed retrospectively to investigate a probable cut off value corresponding to acute coronary disease or non cardiac disorder (Intervention: retrospective echographic myocardial strain analysis refering to acute coronary syndrome).

retrospective echographic myocardial strain analysis refering to acute coronary syndrome

Intervention Type: OTHER

retrospective evaluation for cut off value of circumferential and radial echographic strain parameters corresponding to acute coronary disease

Interventions

retrospective echographic myocardial strain analysis refering to acute coronary syndrome

retrospective evaluation for cut off value of circumferential and radial echographic strain parameters corresponding to acute coronary disease

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• thoracal cardiac or non cardiac disorder
• signed informed consent

Exclusion Criteria

• glomerular filtration rate (GFR) < 60 ml/min
• angina pectoris
• acute myocardial infarction within 3 months prior inclusion
• pregnancy

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

RWTH Aachen University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Joerg Schroeder, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Aachen, Clinic of Cardiology, Angiology, Pneumology and Intensive Care Medicine

Locations

Department of Cardiology, RWTH Aachen University Hospital

Aachen, North Rhine-Westphalia, Germany

Countries

Germany

References

Schroeder J, Hamada S, Grundlinger N, Rubeau T, Altiok E, Ulbrich K, Keszei A, Marx N, Becker M. Myocardial deformation by strain echocardiography identifies patients with acute coronary syndrome and non-diagnostic ECG presenting in a chest pain unit: a prospective study of diagnostic accuracy. Clin Res Cardiol. 2016 Mar;105(3):248-56. doi: 10.1007/s00392-015-0916-2. Epub 2015 Sep 8.

Reference Type: DERIVED

PMID: 26349786 (View on PubMed)

Other Identifiers

CTC-A 13-089

Identifier Type: -

Identifier Source: org_study_id