Magnetic Resonance Imaging In Acute ST-Elevation Myocardial Infarction

NCT ID: NCT04113356

Last Updated: 2021-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2031-06-30

Brief Summary

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Cardiovascular magnetic resonance imaging enables comprehensive assessment of cardiovascular function, morphology and pathology. The investigators aim to evaluate the nature and clinical significance of magnetic resonance imaging parameters in patients presenting with first acute ST-elevation myocardial infarction.

Detailed Description

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Conditions

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Acute ST-Elevation Myocardial Infarction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ST-Elevation Myocardial Infarction

Patients with acute ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Cardiovascular Magnetic Resonance Imaging

Intervention Type DIAGNOSTIC_TEST

Cardiovascular magnetic resonance imaging will be performed within the first week after ST-elevation myocardial infarction and in a defined subgroup 4 months, 12 months and 10 years thereafter.

Interventions

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Cardiovascular Magnetic Resonance Imaging

Cardiovascular magnetic resonance imaging will be performed within the first week after ST-elevation myocardial infarction and in a defined subgroup 4 months, 12 months and 10 years thereafter.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* First ST-elevation myocardial infarction according to the European Society of Cardiology/American College of Cardiology committee criteria
* Primary percutaneous coronary intervention within 24 hours after symptom onset

Exclusion Criteria

* Age \< 18 years
* Any history of a previous myocardial infarction or coronary intervention
* Clinically unstable patients (Killip class \>2)
* Renal failure (estimated glomerular filtration rate \< 30 ml/min/1.73 m2)
* Contraindications to cardiac magnetic resonance imaging (pacemaker, cerebral aneurysm clip, orbital foreign body, known or suggested contrast allergy to gadolinium, claustrophobia)
* Inability to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University Innsbruck

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bernhard Metzler, MD, MSc

Role: PRINCIPAL_INVESTIGATOR

University Hospital for Internal Medicine III (Cardiology and Angiology)

Locations

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University Hospital for Internal Medicine III (Cardiology and Angiology)

Innsbruck, , Austria

Site Status RECRUITING

University Hospital for Radiology

Innsbruck, , Austria

Site Status RECRUITING

Countries

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Austria

Central Contacts

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Bernhard Metzler, MD, MSc

Role: CONTACT

Gert Klug, MD

Role: CONTACT

Facility Contacts

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Bernhard Metzler, MD, MSc

Role: primary

Agnes Mayr, MD

Role: primary

References

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Lechner I, Reindl M, von der Emde S, Desheva A, Oberhollenzer F, Tiller C, Holzknecht M, Kremser T, Faccini J, Gollmann-Tepekoylu C, Kremser C, Mayr A, Bauer A, Metzler B, Reinstadler SJ. Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications. Circ Cardiovasc Imaging. 2024 Dec;17(12):e017041. doi: 10.1161/CIRCIMAGING.124.017041. Epub 2024 Nov 29.

Reference Type DERIVED
PMID: 39611252 (View on PubMed)

Tiller C, Holzknecht M, Lechner I, Oberhollenzer F, von der Emde S, Kremser T, Gollmann-Tepekoylu C, Mayr A, Bauer A, Metzler B, Reinstadler SJ, Reindl M. Association of Circulating PCSK9 With Ischemia-Reperfusion Injury in Acute ST-Elevation Myocardial Infarction. Circ Cardiovasc Imaging. 2024 Aug;17(8):e016482. doi: 10.1161/CIRCIMAGING.123.016482. Epub 2024 Aug 20.

Reference Type DERIVED
PMID: 39163371 (View on PubMed)

Holzknecht M, Tiller C, Reindl M, Lechner I, Fink P, Lunger P, Mayr A, Henninger B, Brenner C, Klug G, Bauer A, Metzler B, Reinstadler SJ. Association of C-Reactive Protein Velocity with Early Left Ventricular Dysfunction in Patients with First ST-Elevation Myocardial Infarction. J Clin Med. 2021 Nov 24;10(23):5494. doi: 10.3390/jcm10235494.

Reference Type DERIVED
PMID: 34884196 (View on PubMed)

Tiller C, Reindl M, Holzknecht M, Lechner I, Schwaiger J, Brenner C, Mayr A, Klug G, Bauer A, Metzler B, Reinstadler SJ. Association of plasma interleukin-6 with infarct size, reperfusion injury, and adverse remodelling after ST-elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2022 Feb 8;11(2):113-123. doi: 10.1093/ehjacc/zuab110.

Reference Type DERIVED
PMID: 34849677 (View on PubMed)

Lechner I, Reindl M, Tiller C, Holzknecht M, Niederreiter S, Mayr A, Klug G, Brenner C, Bauer A, Metzler B, Reinstadler SJ. Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction. Int J Cardiovasc Imaging. 2022 Jan;38(1):237-247. doi: 10.1007/s10554-021-02383-0. Epub 2021 Sep 2.

Reference Type DERIVED
PMID: 34476665 (View on PubMed)

Reindl M, Lechner I, Tiller C, Holzknecht M, Rangger A, Mayr A, Theurl M, Klug G, Brenner C, Bauer A, Metzler B, Reinstadler SJ. Glycemic Status and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Imaging. 2021 Sep;14(9):1875-1877. doi: 10.1016/j.jcmg.2021.04.007. Epub 2021 May 19. No abstract available.

Reference Type DERIVED
PMID: 34023265 (View on PubMed)

Reindl M, Tiller C, Holzknecht M, Lechner I, Eisner D, Riepl L, Pamminger M, Henninger B, Mayr A, Schwaiger JP, Klug G, Bauer A, Metzler B, Reinstadler SJ. Global longitudinal strain by feature tracking for optimized prediction of adverse remodeling after ST-elevation myocardial infarction. Clin Res Cardiol. 2021 Jan;110(1):61-71. doi: 10.1007/s00392-020-01649-2. Epub 2020 Apr 15.

Reference Type DERIVED
PMID: 32296969 (View on PubMed)

Other Identifiers

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AN3775

Identifier Type: -

Identifier Source: org_study_id

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