Low-Dose Dobutamine Tc-99m-Mibi Gated SPECT to Predict Left Ventricular Remodelling in Patients Reperfused in the Acute Phase of MI

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-12-31

Study Completion Date

2008-09-30

Brief Summary

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Left myocardial infarction (MI), has a negative impact of long term morbidity and mortality. Even in patients treated successfully by angioplasty in the acute phase of infarct, the remodelling is observed in approximately 30% of cases. It is important to predict the occurrence of this phenomenon in the early phase after MI for the selection of patients who could eventually benefit from new therapeutic approach as for example cell replacement therapy. It has been advocated that stem cells coronary injections should be performed between the 5th and 10th day after an acute event. We hypothesise that a low dose dobutamine gated Tc-99m-mibi SPECT performed on 5th-6th day after reperfused acute MI can predict left ventricular remodelling and serve as a method to screen patients who could benefit from cell replacement therapy.

Detailed Description

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All patients will be evaluated by ce-MRI during the initial hospital stay (5th - 6th day) and at 6-month follow-up. Left ventricular remodelling will be defined as an end-diastolic volume increase of \>20% between the two exams. A low dose dobutamine gated Tc-99m-mibi SPECT will be also performed on 5th-6th day. Differences in the infarct size and severity as well as the residual inotrope reserve in the infarct area are expected between groups with and without remodelling.

Conditions

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Ischemic Heart Disease Myocardial Infarction

Keywords

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Acute myocardial infarction left ventricular remodelling SPECT imaging

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Low-dose dobutamine Tc-99-m-mibi gated SPECT imaging

All patients will be evaluated by ce-MRI during the initial hospital stay (5th - 6th day)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Acute myocardial infarction,
* Successful coronary angioplasty in the acute phase,
* Absence of heart failure in the acute phase

Exclusion Criteria

* acute heart failure in the acute phase
* severe ventricular arrhythmias
* contra indications for MRI imaging

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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CHU Clermont-Ferrand

Principal Investigators

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Lipiecki Janusz, Dr

Role: PRINCIPAL_INVESTIGATOR

Locations

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CHU de Clermont-Ferrand

Clermont-Ferrand, Auvergne, France

Site Status

Countries

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France

References

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Ernande L, Cachin F, Chabrot P, Durel N, Morand D, Boyer L, Maublant J, Lipiecki J. Rest and low-dose dobutamine Tc-99m-mibi gated-SPECT for early prediction of left ventricular remodeling after a first reperfused myocardial infarction. J Nucl Cardiol. 2009 Jul-Aug;16(4):597-604. doi: 10.1007/s12350-009-9098-5. Epub 2009 May 29.

Reference Type DERIVED

PMID: 19479315 (View on PubMed)

Other Identifiers

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CHU63-0017

Identifier Type: -

Identifier Source: org_study_id