Effect of Significant Ischemic Mitral Regurgitation on the Outcome of ST Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention

NCT ID: NCT04106648

Last Updated: 2020-01-22

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 134 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-11-01
• Study Completion Date: 2023-09-20

Brief Summary

The goal of the study is to correlate the effect of ischemic mitral regurgitation on the outcome of STEMI patients treated with successful primary PCI using clinical data and echocardiography on presentation and during short term follow up after 3 months

Detailed Description

• IMR is defined as mitral regurgitation (MR) caused by chronic changes of LV structure and function due to ischemic heart disease. It is not a valve disease but represents the valvular consequences of increased tethering forces and reduced closing forces. It is reported in approximately one-fifth of patients following acute myocardial infarction (MI) and one-half of those with congestive heart failure. IMR is a frequent complication of coronary artery disease and it worsens the prognosis.
• It is important to distinguish between primary MR due to organic disease of one or more components of the mitral valve apparatus and secondary MR which is not a valve disease, but represents LV disease. Secondary MR is defined as functional MR, due to LV remodeling by cardiomyopathy or coronary artery disease. In the latter clinical setting, secondary functional MR is called IMR. There are some limitations in this definition of functional IMR. Recent studies have revealed evidence of structural changes in the mitral leaflets in response to tethering on them by LV pathological remodeling. The leaflet adaptation includes enlargement and increased stiffness.
• Aim of the work :

To correlate the effect of ischemic mitral regurgitation on the outcome of STEMI patients treated with successful primary PCI using clinical data and echocardiography on presentation and during short term follow up after 3 months

Conditions

Ischemic Mitral Regurgitation

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Subjects with first presentation

2. Subjects with Acute STEMI

3. Subjects undergoing Primary PCI with Successful reperfusion

4. Subjects with significant IMR Grade (III/IV) to (IV/IV)

5. Subjects with acute STEMI with no or non-significant MR undergoing Primary PCI undergoing primary PCI with successful reperfusion (as control)

Exclusion Criteria

1. Rheumatic mitral regurge

2. Valvular mitral regurge

3. IMR Grade (II/IV)

4. Cardiomyopathies

5. Associated other valvular heart diseases

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Fady Usama Amin Kostandy

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Fady Usama Kostandy, Msc

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Hatem Abd El Rahman, Professor

Role: STUDY_DIRECTOR

Assiut University

Magdy Ibrahim Eldesowky, Lecturer

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

Fady Usama Kostandy, Msc

Role: CONTACT

f.usama.kostandy@gmail.com

1277895809 ext. +20

Study Documents

Document Type: Pubmed

View Document

Other Identifiers

Ischemic mitral regurgitation

Identifier Type: -

Identifier Source: org_study_id