Sperm DNA Fragmentation Effects on Blastocyst Morphology Grading, Pregnancy Rate and Implantation Rate
NCT ID: NCT04144621
Last Updated: 2019-11-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
189 participants
OBSERVATIONAL
2018-01-01
2019-04-01
Brief Summary
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Detailed Description
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Method: Retrospective cohort study for 189 couples, assigned to normal SDF group (121 cases), and abnormal SDF group (68 cases). Semen in both groups was processed by double layer density gradient (DG).
Statistical analysis done using SPSS version 22.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Normal SDF
Couples with male partners having SDF lower than 20% using TUNEL assay
ICSI
Intracytoplasmic sperm injection of female partner oocytes with ejaculated sperm selected by density gradient centrifugation
Abnormal SDF
Couples with male partners having SDF greater than 20% using TUNEL assay
ICSI
Intracytoplasmic sperm injection of female partner oocytes with ejaculated sperm selected by density gradient centrifugation
Interventions
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ICSI
Intracytoplasmic sperm injection of female partner oocytes with ejaculated sperm selected by density gradient centrifugation
Eligibility Criteria
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Inclusion Criteria
* Female age ≤37 years old.
* Male sperm count ≥ 5 million.
Exclusion Criteria
* Testicular aspiration or testicular biopsies.
* Oocyte or sperm donation.
37 Years
ALL
No
Sponsors
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Ganin Fertility Center
OTHER
Responsible Party
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Principal Investigators
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Manar Hozyen, MSc
Role: PRINCIPAL_INVESTIGATOR
Ganin Fertility Center
Eman Hassanen, BSc
Role: PRINCIPAL_INVESTIGATOR
Ganin Fertility Center
Hosam Zaki, MSc, FRCOG
Role: STUDY_CHAIR
Ganin Fertility Center
Hanaa El Khedr
Role: PRINCIPAL_INVESTIGATOR
Ganin Fertility Center
Yasmine Azzouz, BSc
Role: PRINCIPAL_INVESTIGATOR
Ganin Fertility Center
Locations
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Ganin Fertility Center
Cairo, , Egypt
Countries
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References
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Wdowiak A, Bojar I. Relationship between pregnancy, embryo development, and sperm deoxyribonucleic acid fragmentation dynamics. Saudi J Biol Sci. 2016 Sep;23(5):598-606. doi: 10.1016/j.sjbs.2015.08.001. Epub 2015 Aug 10.
Gat I, Tang K, Quach K, Kuznyetsov V, Antes R, Filice M, Zohni K, Librach C. Sperm DNA fragmentation index does not correlate with blastocyst aneuploidy or morphological grading. PLoS One. 2017 Jun 7;12(6):e0179002. doi: 10.1371/journal.pone.0179002. eCollection 2017.
Alvarez Sedo C, Bilinski M, Lorenzi D, Uriondo H, Noblia F, Longobucco V, Lagar EV, Nodar F. Effect of sperm DNA fragmentation on embryo development: clinical and biological aspects. JBRA Assist Reprod. 2017 Dec 1;21(4):343-350. doi: 10.5935/1518-0557.20170061.
Other Identifiers
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MH0001
Identifier Type: -
Identifier Source: org_study_id
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