Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-01

Study Completion Date

2011-04-30

Brief Summary

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A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode. Weaning outcomes were compared between 2 groups.

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Detailed Description

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Pressure support ventilation (PSV) the most frequently used mode of ventilator support in intensive care units, but has several demerits. Proportional assist ventilation with load-adjustable gain factors (PAV+) is a promising mode with better patient synchrony and weaning advantages. However, weaning outcome of PAV+ in patients with prolonged mechanical ventilation has not been evaluated before. We conducted a prospective randomized controlled trial in a tertiary medical center. This study aimed to compare the effectiveness between PAV+ and PSV for weaning adult patients with prolonged mechanical ventilation.

Conditions

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Respiratory Failure Respiration, Artificial

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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PAV+ mode

Weaning with PAV+ mode

Group Type EXPERIMENTAL

PAV+ mode

Intervention Type DEVICE

PAV+ mode by using Puritan-Bennett 840 ventilator

PSV mode

Weaning with PSV mode

Group Type ACTIVE_COMPARATOR

PSV mode

Intervention Type DEVICE

PSV mode by using Puritan-Bennett 840 ventilator

Interventions

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PAV+ mode

PAV+ mode by using Puritan-Bennett 840 ventilator

Intervention Type DEVICE

PSV mode

PSV mode by using Puritan-Bennett 840 ventilator

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients with prolonged mechanical ventilation and transfer to respiratory care center, age of 20 years or older, at least 1 time of extubation failure or spontaneous breathing trial failure in ICU, stable hemodynamics, no vasopressor use, FiO2 = 0.40 or less, external positive end-expiratory pressure = 5 cmH2O or less, PaO2 \> 60 mmHg, and body temperature \< 38ºC (within 24 hours).