Comparison of Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-02-28

Brief Summary

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In spontaneously breathing mechanically ventilated patients, the adequacy between the patient's demand and the level of respiratory support delivered by the ventilator is a major clinical issue. Neurally adjusted ventilator assist (NAVA) and proportional assist ventilation (PAV) have been developed to adapt the level of assistance to the patient's demand. These two modes have been compared to pressure support ventilation (PSV) but have not been compared to each other.

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Detailed Description

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Conditions

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Acute Respiratory Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intubated patients

Intubated patients: The three modes (PSV, PAV, NAVA) will be applied in random order to each mechanically ventilated patient included in the study.

Group Type EXPERIMENTAL

PSV mode

Intervention Type DEVICE

Application of PSV in all patients

PAV mode

Intervention Type DEVICE

Application of PAV mode in all patients

NAVA

Intervention Type DEVICE

Interventions

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PSV mode

Application of PSV in all patients

Intervention Type DEVICE

PAV mode

Application of PAV mode in all patients

Intervention Type DEVICE

NAVA

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Intubated patients.
* Mechanical ventilation for a respiratory reason.
* Expected duration of Mechanical ventilation \> 48 hrs.
* Spontaneous breathing.
* Sedations stopped for more than 24 hours.

Exclusion Criteria

* \- Main contra indications to NAVA: gastro-oesophageal surgery in the previous 12 months, oesophageal obstruction, gastro-esophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma or surgery, neuromuscular diseases, individuals with known or suspected phrenic nerve dysfunction.
* Main contra indications to PAV: airway leak, body weight \<25 kg, neuromuscular diseases.
* Hemodynamic instability defined as the current administration of vasopressors or inotropic drugs.
* Severe hypoxemia defined as PaO2/FiO2 ratio \<200.
* Decision to withhold life-sustaining treatment.
* Pregnant women.
* Minors \< 18 years.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No