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Impact of Neurally Adjusted Ventilator Assist (NAVA) Mode on Patient Ventilator Asynchrony Using Non-invasive Ventilation (NAVA-NIV)

NCT ID: NCT01280760

Last Updated: 2013-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

16 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-05-31

Brief Summary

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Non-invasive ventilation (NIV) has been proposed to reduce the incidence of ventilatory dysfunction following mechanical ventilation weaning. However, the nasogastric tube reduces the airtightness of the facial mask used to perform non-invasive ventilation and induces air leaks. The presence of leaks at the patient-mask interface can increase the risk of patient-ventilator asynchrony, which in turn leads to increase patient discomfort. Neurally adjusted ventilatory assist (NAVA)could contribute to decreasing asynchrony. Its principle is to record the diaphragmatic electrical activity and to control the ventilator. The investigators hypothesized driving the ventilator based on a neural signal (diaphragm electrical activity) would reduce patient-ventilator asynchronies in NIV

Detailed Description

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Conditions

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Weaning Period

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Non invasive ventilation

Non-invasive ventilation after invasive mechanical ventilation weaning

Device: Neurally Adjusted Ventilatory Assistance

Intervention Type OTHER

Device: Neurally Adjusted Ventilatory Assistance

In ICU following extubation NIV was performed as follows:

facial mask with PSV/NIV mode to define settings for NAVA ventilation facial use with NAVA/NIV mode

Interventions

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Device: Neurally Adjusted Ventilatory Assistance

Device: Neurally Adjusted Ventilatory Assistance

In ICU following extubation NIV was performed as follows:

facial mask with PSV/NIV mode to define settings for NAVA ventilation facial use with NAVA/NIV mode

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Patients with increased risk of post-extubation ventilatory dysfunction following invasive mechanical ventilation weaning.

Exclusion Criteria

* Contra-indication to non-invasive ventilation
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pierre and Marie Curie University

OTHER

Sponsor Role lead

Responsible Party

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Matthieu SCHMIDT

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Groupe Hospitalier Pitié Salpétrière, Department of intensive care and pneumology

Paris, , France

Site Status

Countries

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France

References

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Schmidt M, Dres M, Raux M, Deslandes-Boutmy E, Kindler F, Mayaux J, Similowski T, Demoule A. Neurally adjusted ventilatory assist improves patient-ventilator interaction during postextubation prophylactic noninvasive ventilation. Crit Care Med. 2012 Jun;40(6):1738-44. doi: 10.1097/CCM.0b013e3182451f77.

Reference Type DERIVED
PMID: 22610179 (View on PubMed)

Other Identifiers

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UPMC

Identifier Type: -

Identifier Source: org_study_id