Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation
NCT ID: NCT00911378
Last Updated: 2009-06-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
130 participants
INTERVENTIONAL
2008-04-30
2009-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
TRIPLE
Study Groups
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Pressure support ventilation
Patients in this arm are weaned by gradual reduction of pressure support
Pressure support ventilation
These patients are weaned by gradual reduction of pressure support and extubated when they tolerate a pressure support of 7 cm of water for one hour.
Spontaneous breathing trials
Patients in this arm are weaned by T piece trials
Spontaneous breathing trials
These patients are weaned by giving a T piece trial with 8 cm of water pressure support and extubated when they tolerate it for one hour.
Interventions
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Pressure support ventilation
These patients are weaned by gradual reduction of pressure support and extubated when they tolerate a pressure support of 7 cm of water for one hour.
Spontaneous breathing trials
These patients are weaned by giving a T piece trial with 8 cm of water pressure support and extubated when they tolerate it for one hour.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Satisfies weaning criteria
* RSBI \< 80
* Ratio of PaO2/FiO2 \> 250
* Arterial partial pressure of oxygen more than 60 mm Hg and carbon dioxide less than 50 mm Hg
Exclusion Criteria
* Arterial partial pressure of oxygen less than 60 mm Hg
* Poor sensorium
10 Years
70 Years
ALL
No
Sponsors
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Post Graduate Institute of Medical Education and Research, Chandigarh
OTHER
Responsible Party
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Postgraduate Institute of Medical Education and Research
Principal Investigators
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Dr. Ashutosh Aggarwal, MD, DM
Role: STUDY_DIRECTOR
Department of Pulmonary Medicine and Critical Care, Postgraduate Institute of Medical Education and Research
Locations
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Postgraduate Institute of Medical Education and Research
Chandigarh, Chandigarh, India
Countries
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Central Contacts
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Facility Contacts
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References
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Esteban A, Frutos F, Tobin MJ, Alia I, Solsona JF, Valverdu I, Fernandez R, de la Cal MA, Benito S, Tomas R, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med. 1995 Feb 9;332(6):345-50. doi: 10.1056/NEJM199502093320601.
Brochard L, Rauss A, Benito S, Conti G, Mancebo J, Rekik N, Gasparetto A, Lemaire F. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med. 1994 Oct;150(4):896-903. doi: 10.1164/ajrccm.150.4.7921460.
Esteban A, Alia I, Gordo F, Fernandez R, Solsona JF, Vallverdu I, Macias S, Allegue JM, Blanco J, Carriedo D, Leon M, de la Cal MA, Taboada F, Gonzalez de Velasco J, Palazon E, Carrizosa F, Tomas R, Suarez J, Goldwasser RS. Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. The Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):459-65. doi: 10.1164/ajrccm.156.2.9610109.
Other Identifiers
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weaning2009
Identifier Type: -
Identifier Source: org_study_id
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