Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis

NCT ID: NCT04083482

Last Updated: 2019-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-20

Study Completion Date

2019-12-31

Brief Summary

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The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation(CVVH)

Detailed Description

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Continous renal replacement therapy (CRRT)has become routine for patients with chronic renal failure ,AKI,fliud overload as well as oliguria in ICU .In clinical patients ,continous venovenous hemofoiltration (CVVH)is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ,improving oxygen index,increasing cardiac index and regulating immune dysfuntion .

Conditions

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Intensive Care Unit

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Septic patients require CVVH

continuous venovenous hemofiltration. Continuous renal replacement therapy(CRRT)has become routine for patients with chronic renal failure ,AKI,fliud overload as well as oliguria in ICU .Continuous venovenous hemofiltration(CVVH)is the method of chioce for CRRT in critical ill .CVVH has significant beneficial effects on removing inflammatory cytokines ,improving oxygen index ,decreasing vasopressor requirements,increasing cardiac index and regulating immune dysfunction .

Group Type EXPERIMENTAL

continous venovenous hemofiltraion

Intervention Type PROCEDURE

CVVH

Interventions

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continous venovenous hemofiltraion

CVVH

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Adult septic patients undergoing CRRT

Exclusion Criteria

1. Missing vists
2. transplatation
3. cancer
4. aquired immunodeficiency syndrome
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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First People's Hospital of Chenzhou

OTHER

Sponsor Role lead

Responsible Party

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Xingui Dai

Critical Care Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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dixian luo, MS

Role: STUDY_DIRECTOR

Chenzhou First people Hospital

Locations

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The First Hospital of Chenzhou

Chenzhou, Hunan, China

Site Status

Countries

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China

Other Identifiers

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WYJ2019

Identifier Type: -

Identifier Source: org_study_id

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