The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis

NCT ID: NCT01501097

Last Updated: 2011-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Brief Summary

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The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis

Detailed Description

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The impact of Continuous Renal Replacement Therapy (CRRT) on the outcomes of patients with sepsis is controversial, and there is no consensus for the timing and dose of CRRT may improve the outcomes. The purpose of this prospective randomized study is to assess the effect of different CRRT intensity (25ml/kg/h or 50ml/kg/h) on the outcomes of burn patients with early phase of sepsis

Conditions

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Burns Sepsis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control group

Group Type NO_INTERVENTION

Continuous Renal Replacement Therapy

Intervention Type PROCEDURE

Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group

early HV-crrt

Group Type EXPERIMENTAL

Continuous Renal Replacement Therapy

Intervention Type PROCEDURE

Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group

Interventions

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Continuous Renal Replacement Therapy

Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients with documented sepsis
* clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion
* age 18 to 70 years
* severe burned patients with 50% \< TBSA \< 85%

Exclusion Criteria

* cirrhosis child class C
* too high APACHE II \& SOFA score at admission
* age over 70 years
* were presence of a malignant tumor, chronic renal insufficiency (serum creatinine \> 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Southwest Hospital, China

OTHER

Sponsor Role lead

Responsible Party

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Zhiqiang Yuan

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Southwest Hospital

Chongqing, Chongqing Municipality, China

Site Status

Countries

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China

Other Identifiers

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SWHCBS01

Identifier Type: -

Identifier Source: org_study_id