Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient
NCT ID: NCT04169412
Last Updated: 2019-11-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
72 participants
OBSERVATIONAL
2019-02-22
2019-08-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Resuscitation Failure, High PCO Level, High RIPK3 Level
1. Resuscitation failure was defined as lactate level ≥2 mmol/L or lactate reduction \<20% hour-4 after initial sepsis recognition.
2. High PCO level was defined as PCO level ≥ cut off point.
3. High RIPK3 level was defined as PCO level ≥ cut off point.
Blood Collection
Blood Gas Analysis using Stat Profile pHOx® Series (nova biomedical, Waltham, U.S.) and Enzym-linked Immunosorbent Assay (ELISA) using Bio-Rad (Bio-Rad Laboratories, California, U.S.)
Resuscitation Success, Low PCO Level, Low RIPK3 Level
1. Resuscitation success was defined as lactate level \<2 mmol/L or lactate reduction ≥20% hour-4 after initial sepsis recognition.
2. Low PCO level was defined as PCO level \< cut off point.
3. Low RIPK3 level was defined as PCO level \< cut off point.
Blood Collection
Blood Gas Analysis using Stat Profile pHOx® Series (nova biomedical, Waltham, U.S.) and Enzym-linked Immunosorbent Assay (ELISA) using Bio-Rad (Bio-Rad Laboratories, California, U.S.)
Interventions
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Blood Collection
Blood Gas Analysis using Stat Profile pHOx® Series (nova biomedical, Waltham, U.S.) and Enzym-linked Immunosorbent Assay (ELISA) using Bio-Rad (Bio-Rad Laboratories, California, U.S.)
Eligibility Criteria
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Inclusion Criteria
* Diagnosed sepsis using Sepsis-3 definition
Exclusion Criteria
* Not treated at the ICU
* Had a late diagnosis (\>24 h)
* Pregnant
* Brain dead
18 Years
ALL
No
Sponsors
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Indonesia University
OTHER
Universitas Sriwijaya
OTHER
Responsible Party
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Mayang Indah Lestari
Principal Investigator
Locations
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Mohammad Hoesin Central General Hospital
Palembang, South Sumatera, Indonesia
Countries
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References
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Other Identifiers
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047/kepkrsmhfkunsri/2019
Identifier Type: -
Identifier Source: org_study_id
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