Neural Mechanisms Underlying Astigmatism

NCT ID: NCT03735602

Last Updated: 2020-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-01

Study Completion Date

2021-12-31

Brief Summary

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This study is to compare the contrast sensitivity function and neural response to gratings before and after the orientation discrimination task in the astigmatism or amblyopia patients.

Detailed Description

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The presence of astigmatism can lead to substantial reductions in visual performance in a variety of clinical vision measures and functional visual tasks. However, the neural mechanisms underlying the astigmatism remains unknown. The current study recruited three groups (patients with with-the-rule astigmatism and amblyopia, patients with with-the-rule astigmatism but without amblyopia, normal controls) of subjects and patients receive perceptual learning training (orientation discrimination task) which lasts for around 15 days. This main aim is to compare the contrast sensitivity function and neural response to gratings before and after the orientation discrimination task in the astigmatism or amblyopia patients.

Patients with astigmatism or amblyopia were included in this study. All participants underwent an ophthalmic examination that included slit-lamp biomicroscopy, visual acuity, quick CSF under full optical correction, 9-SF life quality questionnaire and fundus examination.

Conditions

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Astigmatism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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perceptual training

Orientation discrimination task, which is a cognitive task. Patients were trained for 1 hour per day, 15 days in total.

Group Type EXPERIMENTAL

perceptual training

Intervention Type BEHAVIORAL

orientation discrimination task

Interventions

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perceptual training

orientation discrimination task

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* high astigmatism

Exclusion Criteria

* other types of disease (especially optical diseases) that may affect study
Minimum Eligible Age

10 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Zhongshan Ophthalmic Center, Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Jin Yuan

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jin Yuan, Professor

Role: STUDY_CHAIR

Zhongshan Ophthalmic Center, Sun Yat-sen University

Locations

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Zhongshan Ophthalmic Center

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Li Gu, Phd

Role: CONTACT

15889937313 ext. +86

Jin Yuan, Professor

Role: CONTACT

2087333391

Facility Contacts

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Li Gu, Dr.

Role: primary

15889937313 ext. +86

Other Identifiers

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JYuan

Identifier Type: -

Identifier Source: org_study_id

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