Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy
NCT ID: NCT04310241
Last Updated: 2025-05-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
150 participants
OBSERVATIONAL
2020-02-21
2027-03-12
Brief Summary
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Detailed Description
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The following visual functions will be measured prior to treatment. Eye movements, contrast sensitivity, grating acuity, visual acuity, vernier acuity, binocular visual functions, reading and visual scanning will be measured. The testing will comprise of one or more of the above paradigms depending on participant's cooperation and understanding as majority of the study participants will be children. The above measurements will be repeated during amblyopia therapy ( which comprises of glasses, patching and/or atropine eye drops) and at the completion of treatment. For participants with strabismus requiring strabismus surgery the measurements will be repeated after strabismus surgery.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Control subjects
Subjects who state they have no eye or neurologic problems or disease other than perhaps wearing glasses or contact lenses and upon review of medical history.
No interventions assigned to this group
Amblyopia
Clinical diagnosis of amblyopia
Patching therapy, Glasses
Patching, glasses and strabismus surgery are commonly employed measures in treatment of amblyopia and strabismus.
Interventions
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Patching therapy, Glasses
Patching, glasses and strabismus surgery are commonly employed measures in treatment of amblyopia and strabismus.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
6 Months
90 Years
ALL
No
Sponsors
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The Cleveland Clinic
OTHER
Responsible Party
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Fatema Ghasia
Associate Staff
Principal Investigators
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Fatema Ghasia, MD
Role: PRINCIPAL_INVESTIGATOR
The Cleveland Clinic
Locations
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Cleveland Clinic
Cleveland, Ohio, United States
Countries
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Central Contacts
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Facility Contacts
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Fatema Ghasia, MD
Role: primary
References
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Shaikh AG, Otero-Millan J, Kumar P, Ghasia FF. Abnormal Fixational Eye Movements in Amblyopia. PLoS One. 2016 Mar 1;11(3):e0149953. doi: 10.1371/journal.pone.0149953. eCollection 2016.
Ghasia FF, Otero-Millan J, Shaikh AG. Abnormal fixational eye movements in strabismus. Br J Ophthalmol. 2018 Feb;102(2):253-259. doi: 10.1136/bjophthalmol-2017-310346. Epub 2017 Jul 11.
Chatzistefanou KI, Theodossiadis GP, Damanakis AG, Ladas ID, Moschos MN, Chimonidou E. Contrast sensitivity in amblyopia: the fellow eye of untreated and successfully treated amblyopes. J AAPOS. 2005 Oct;9(5):468-74. doi: 10.1016/j.jaapos.2005.05.002.
Other Identifiers
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12-915
Identifier Type: -
Identifier Source: org_study_id
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