Understanding Visual Confusion Using Stereoscopic Displays

NCT ID: NCT04957745

Last Updated: 2023-07-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-09

Study Completion Date

2022-07-27

Brief Summary

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In this research study we want to test how people understand a visual scene when the same image is presented to both the eyes, but portions of these images are altered in terms of contrast, depth or in some cases motion.

Detailed Description

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Conditions

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Diplopia Binocular Vision Suppression Binocular; Fusion, With Defective Stereopsis Monocular Diplopia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All participants in the group will see all three interventions (peripheral targets in three visual confusion conditions) in a randomized order. In this study design, each participant will serve as their own control, and the order of the interventions will be randomized to account for potential carryover or ordering effects. There will be no comparison or control group. The outcome will be compared through a within-subject analysis.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Visual confusion

Participants viewed peripheral targets in three different visual confusion conditions (three interventions): binocular visual confusion (unilateral opaque target), unilateral monocular visual confusion (unilateral see-through target), and bilateral monocular visual confusion (bilateral see-through target). Each intervention was presented twice in a randomized order, resulting in a total of six trials. During each trial, a peripheral target was presented in front of a forward-moving background for one minute. Participants were instructed to hold down the controller button while the target was visible and release it when a third or more of the target disappeared. After each trial, participants could take a brief break before the next trial in a different visual confusion condition was presented in a randomized order.

Group Type EXPERIMENTAL

Binocular visual confusion (unilateral opaque)

Intervention Type BEHAVIORAL

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation.

For the binocular visual confusion condition, the non-transparent (opaque) peripheral target will be displayed on only one eye (unilateral opaque display).

Unilateral monocular visual confusion (unilateral see-through)

Intervention Type BEHAVIORAL

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation.

For the unilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on only one eye (unilateral see-through display).

Bilateral monocular visual confusion (bilateral see-through)

Intervention Type BEHAVIORAL

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation.

For bilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on both eyes (bilateral see-through display).

Interventions

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Binocular visual confusion (unilateral opaque)

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation.

For the binocular visual confusion condition, the non-transparent (opaque) peripheral target will be displayed on only one eye (unilateral opaque display).

Intervention Type BEHAVIORAL

Unilateral monocular visual confusion (unilateral see-through)

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation.

For the unilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on only one eye (unilateral see-through display).

Intervention Type BEHAVIORAL

Bilateral monocular visual confusion (bilateral see-through)

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation.

For bilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on both eyes (bilateral see-through display).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Better than 20/40 visual acuity in the worse eye
* No restrictions of the peripheral visual field: (at least 60 degrees vertically and 40 degrees horizontally)
* At least 14 years of age (no upper age limit)
* Able to give voluntary, informed consent
* Able to understand English
* Binocular vision parameters within normal limits (Stereopsis ≤ 100 arc sec on any stereo test)

Exclusion Criteria

* Patients with any physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study will be excluded
* Being unable to complete sessions lasting 2-3 hours
Minimum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Eye Institute (NEI)

NIH

Sponsor Role collaborator

Massachusetts Eye and Ear Infirmary

OTHER

Sponsor Role lead

Responsible Party

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Jaehyun Jung

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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JaeHyun Jung

Role: PRINCIPAL_INVESTIGATOR

Schepens Eye Research Institute

Locations

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Schepens Eye Research Institute

Boston, Massachusetts, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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R01EY031777

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2021P001757

Identifier Type: -

Identifier Source: org_study_id

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