Effect of Genetic Variation in Starch-digesting Enzymes on Digestibility and Glycemic Index of Cold and Hot Rice
NCT ID: NCT03667963
Last Updated: 2019-01-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2018-08-29
2018-12-21
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
FACTORIAL
BASIC_SCIENCE
DOUBLE
Study Groups
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Low Salivary Amylase Activity
Glucose Glucose plus lactulose Hot Rice Cold Rice
Glucose
50g glucose dissolved in 250ml water
Glucose plus lactulose
50g glucose plus 10g lactulose dissolved in 250ml water
Hot Rice
Freshly cooked polished rice containing 50g available carbohydrate (approximately 2/3 cup cooked rice) and consumed hot.
Cold Rice
Cooked polished rice containing 50g available carbohydrate (approximately 2/3 cup cooked rice) cooled overnight in a refrigerator and consumed cold.
High Salivary Amylase Activity
Glucose Glucose plus lactulose Hot Rice Cold Rice
Glucose
50g glucose dissolved in 250ml water
Glucose plus lactulose
50g glucose plus 10g lactulose dissolved in 250ml water
Hot Rice
Freshly cooked polished rice containing 50g available carbohydrate (approximately 2/3 cup cooked rice) and consumed hot.
Cold Rice
Cooked polished rice containing 50g available carbohydrate (approximately 2/3 cup cooked rice) cooled overnight in a refrigerator and consumed cold.
Interventions
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Glucose
50g glucose dissolved in 250ml water
Glucose plus lactulose
50g glucose plus 10g lactulose dissolved in 250ml water
Hot Rice
Freshly cooked polished rice containing 50g available carbohydrate (approximately 2/3 cup cooked rice) and consumed hot.
Cold Rice
Cooked polished rice containing 50g available carbohydrate (approximately 2/3 cup cooked rice) cooled overnight in a refrigerator and consumed cold.
Eligibility Criteria
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Inclusion Criteria
* Eligible to receive income in Canada
* Have Ontario Health Insurance Plan or equivalent medical coverage.
* Previous donor of saliva using protocol reference number # 31093 or GIL-1670 (in which subject consents to measurement of salivary amylase activity and genetic variation in AMY1, SI and MGAM genes).
* Salivary amylase activity in the lowest tertile (\<50 U/ml) or highest tertile (\>105 U/ml) of salivary amylase activity of 40 subjects previously measured.
Exclusion Criteria
* Allergy to rice, canola oil or sesame oil.
* use of medications (including, but not limited to, insulin or other antidiabetic drugs, systemic steroids, antipsychotics, protease inhibitors, antivirals, immunosuppressive agents and drugs affecting gut motility or digestion) or with any condition which might, in the opinion of Dr. Wolever, the Medical Director or GI Labs, either: 1) make participation dangerous to the participant himself (or herself) or to others, or 2) affect the results.
* individuals who cannot or will not comply with the experimental procedures or do not follow the instructions of GI Labs staff related to the safe performance of the experimental procedures
18 Years
75 Years
ALL
Yes
Sponsors
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Glycemic Index Laboratories, Inc
INDUSTRY
University of Toronto
OTHER
Responsible Party
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Thomas Wolever
Professor
Principal Investigators
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Thomas MS Wolever, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
President, Medical Director
Locations
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Glycemic Index Laboratories
Toronto, Ontario, Canada
Countries
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References
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Wolever TMS, El-Sohemy A, Ezatagha A, Zurbau A, Jenkins AL. Neither low salivary amylase activity, cooling cooked white rice, nor single nucleotide polymorphisms in starch-digesting enzymes reduce glycemic index or starch digestibility: a randomized, crossover trial in healthy adults. Am J Clin Nutr. 2021 Nov 8;114(5):1633-1645. doi: 10.1093/ajcn/nqab228.
Other Identifiers
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RIS protocol number 33593
Identifier Type: -
Identifier Source: org_study_id
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