Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-07

Study Completion Date

2022-01-25

Brief Summary

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The purpose of this study is to investigate whether we can improve associative memory performance in healthy subjects, by applying transcranial Direct Current Stimulation (tDCS) during a verbal paired-associate learning task

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Detailed Description

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Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer's disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.

Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. To investigate whether it is possible to improve associative memory using tDCS, the performance in a Verbal Paired-Associate memory task of 4 groups targeting different areas will be compared.

Conditions

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Healthy Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants will be randomly assigned to one of four groups: (1) tDCS targeting location 1 paired with memory task (2) tDCS targeting location 2 with memory task (3) tDCS targeting location 3 paired with memory task (4) tDCS targeting location 4 paired with memory task

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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memory task with tDCS location 1

memory task paired with tDCS targeting C2 nerve (anode left c2; cathode right C2)

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

tDCS

memory task with tDCS location 2

memory task paired with tDCS targeting C2 nerve (anode right c2; cathode left C2)

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

tDCS

memory task with tDCS location 3

memory task paired with tDCS targeting C5/6 nerve

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

tDCS

memory task with tDCS location 4

memory task paired with tDCS targeting trigeminal nerve dermatomes (left and right temple/jaw)

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

tDCS

Interventions

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tDCS

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age: 18-35 years
* Native English Speaker

Exclusion Criteria

* History of severe head injuries, epileptic insults, or heart disease.
* Severe psychiatric disorders and severe untreated medical problems.
* acquainted with the foreign language used in the learning task
* Contraindications for tDCS (pregnant women, implanted devices)

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes