Transcranial Direct Current Stimulation (tDCS) and Cognitive Processing

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

307 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2023-03-02

Brief Summary

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This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities. In this research, battery powered device is used to deliver very weak electrical current to the surface of the scalp while participants complete cognitive tasks. Our aim is to find out whether tDCS will improve task performance in both healthy adults and those with neurological impairment.

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Detailed Description

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Participants enrolled into this study may be asked to do the following:

* Grant permission for the researchers to view medical records associated with their language/cognitive difficulties (if applicable.
* Complete a questionnaire, provide a health history, and take some pencil-and-paper tests of problem-solving and memory in order to verify eligibility to participate and to able to safely undergo the experimental procedures.
* Complete several tasks (i.e., saying words out loud, naming objects, drawing designs, remembering lists of words, searching for images or letters, and/or completing puzzles) based upon a number of cognitive functions such as language, memory, vision, processing, and perception.
* Wear electrodes that will be placed on the scalp with a large rubberized band. These electrodes will administer very weak electrical current (tDCS) from a battery powered device for 20 to 60 minutes.
* Participation in several study conditions. The exact conditions and their order will be randomized. Under some conditions, participants may receive active stimulation (tDCS) and under other conditions, they may receive sham stimulation.
* The experimental sessions will last approximately 2 hours and participants may be asked to have more than one testing session in a day or to return for additional sessions.
* Have a Magnetic Resonance Imaging (MRI) brain scan.

Conditions

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Aphasia Autism Schizophrenia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

* Right handed (as determined by the Edinburgh battery)
* English as native language

* Right handed (as determined by the Edinburgh battery)
* English as native language
* History of acquired left-hemisphere dysfunction

* Right handed (as determined by the Edinburgh battery)
* English as native language
* Diagnosis of schizophrenia (SZ) or bipolar disorder (BD)
* First degree family member of individual with SZ or BD

* Right handed (as determined by the Edinburgh battery)
* English as native language
* Diagnosis of High-functioning autism (i.e., Asperger's)

Exclusion Criteria

* Appreciable deficits in hearing
* Appreciable problems with articulation
* Schizophrenia, bipolar disorder, or major depression
* Appreciable accent
* Any neurological disorder associated with cognitive impairment or neuroanatomic abnormality
* Language-based learning disorder
* Any implanted metal device (precludes use of tDCS)
* Any implanted cardiac pacemaker
* Dementia or Mini-Mental State Exam \< 24
* Estimated verbal intelligence \< 70

* Appreciable deficits in hearing
* Schizophrenia, bipolar disorder, or major depression
* Appreciable accent
* Language-based learning disorder
* Any implanted metal device
* Any implanted cardiac pacemaker
* Mini-Mental State Exam \< 21/27 (omitting naming \& items)
* Estimated verbal intelligence \< 70

* Appreciable deficits in hearing
* Appreciable accent
* Any implanted metal device (precludes use of tDCS)
* Any implanted cardiac pacemaker
* Dementia or Mini-Mental State Exam \< 24
* Estimated verbal intelligence \< 70

* Appreciable deficits in hearing
* Schizophrenia, bipolar disorder, or major depression
* Appreciable accent
* Any implanted metal device
* Any implanted cardiac pacemaker
* Dementia or Mini-Mental State Exam \< 24
* Estimated verbal intelligence \< 70

Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes