Neurobehavioral Plasticity to Regular Sugar-Sweetened Beverage Intake: An fMRI Experiment
NCT ID: NCT03490734
Last Updated: 2023-04-06
Study Results
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View full resultsBasic Information
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COMPLETED
NA
160 participants
INTERVENTIONAL
2018-04-10
2022-03-18
Brief Summary
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Detailed Description
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Regular SSB intake is considered a contributing factor to excess energy intake, weight gain, and obesity, which impacts 70% of Americans. A contributing factor to repeated SSB consumption is sugar intake causes the release of dopamine (DA) and opioids in the striatum, providing positive reinforcement. As such, multiple brain-based models of food reward-driven obesity have been proposed, largely focusing on the striatum and executive functioning. These brain-based models of obesity have elucidated risk factors for overconsumption of high-sugar foods; however, data supporting these competing models rely heavily on observational studies in small samples.
Importantly, previous reports from the investigators lab and others directly implicate eating behavior patterns as a vital contributor to aberrant neurobehavioral responses to food stimuli. However, without experimental evidence, there are fundamental gaps in the investigators knowledge about the neurobehavioral adaptations that occur as an individual begins to regularly consume a SSB prior to weight change.
As observational data suggest, it is also crucial to examine individual difference factors that may exacerbate or protect against adaptations associated with regular SSB intake, as well as whether these adaptions are specific.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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Beverage A (Sweetened)
One quarter of the group to receive black cherry and orange flavored beverage with added sugar for 3 weeks.
MRIs will be performed before starting and then after 3 weeks of daily beverage consumption wherein participants will be presented with visual stimuli of two beverage logos, one representing a water solution and another representing the assigned beverage. Each 1-second presentation signals impending delivery of 3 mL of the associated beverage via a plastic mouthpiece during MRI.
Black Cherry and Orange Flavored Beverage with added sugar
10 oz daily for three weeks
Water
Three mL administered per associated logo presentation only during MRI procedure.
Beverage B (Sweetened)
One quarter of the group to receive strawberry kiwi \& lemonade flavored beverage with added sugar for 3 weeks.
MRIs will be performed before starting and then after 3 weeks of daily beverage consumption wherein participants will be presented with visual stimuli of two beverage logos, one representing a water solution and another representing the assigned beverage. Each 1-second presentation signals impending delivery of 3 mL of the associated beverage via a plastic mouthpiece during MRI.
Strawberry Kiwi &Lemonade Flavored Beverage with added sugar
10 oz daily for three weeks
Water
Three mL administered per associated logo presentation only during MRI procedure.
Beverage A (Unsweetened)
One quarter of the group to receive black cherry and orange flavored beverage no added sugar for 3 weeks.
MRIs will be performed before starting and then after 3 weeks of daily beverage consumption wherein participants will be presented with visual stimuli of two beverage logos, one representing a water solution and another representing the assigned beverage. Each 1-second presentation signals impending delivery of 3 mL of the associated beverage via a plastic mouthpiece during MRI.
Black Cherry and Orange Flavored Beverage no added sugar
10 oz daily for three weeks
Water
Three mL administered per associated logo presentation only during MRI procedure.
Beverage B (Unsweetened)
One quarter of the group to receive strawberry kiwi \& lemonade flavored beverage no added sugar for 3 weeks.
MRIs will be performed before starting and then after 3 weeks of daily beverage consumption wherein participants will be presented with visual stimuli of two beverage logos, one representing a water solution and another representing the assigned beverage. Each 1-second presentation signals impending delivery of 3 mL of the associated beverage via a plastic mouthpiece during MRI.
Strawberry Kiwi & Lemonade Flavored Beverage no added sugar
10 oz daily for three weeks
Water
Three mL administered per associated logo presentation only during MRI procedure.
Interventions
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Black Cherry and Orange Flavored Beverage with added sugar
10 oz daily for three weeks
Strawberry Kiwi &Lemonade Flavored Beverage with added sugar
10 oz daily for three weeks
Black Cherry and Orange Flavored Beverage no added sugar
10 oz daily for three weeks
Strawberry Kiwi & Lemonade Flavored Beverage no added sugar
10 oz daily for three weeks
Water
Three mL administered per associated logo presentation only during MRI procedure.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* current regular use (3 or more times a week) of psychoactive drugs (e.g., cocaine, marijuana, nicotine),
* regular smoking,
* serious medical problems (e.g., cancer, diabetes),
* dietary practices that do not allow intake of intervention beverages.
18 Years
28 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of North Carolina, Chapel Hill
OTHER
Responsible Party
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Principal Investigators
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Kyle Burger, PhD
Role: PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill
Locations
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Mcgavran-Greenberg Hall
Chapel Hill, North Carolina, United States
Countries
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References
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Peirce JW. PsychoPy--Psychophysics software in Python. J Neurosci Methods. 2007 May 15;162(1-2):8-13. doi: 10.1016/j.jneumeth.2006.11.017. Epub 2007 Jan 23.
Provided Documents
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Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Other Identifiers
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17-0710
Identifier Type: -
Identifier Source: org_study_id
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