Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
23 participants
INTERVENTIONAL
2018-10-24
2021-05-31
Brief Summary
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Detailed Description
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Hypothesis: Compared to pre, post-RT fMRI measures will demonstrate ↓ neuronal responses to food cues in the insula, prefrontal cortex, and hypothalamus, brain regions implicated in reward, impulsivity, motivation, and regulation of ingestive behaviors. These changes will be associated with ad libitum EI.
Aim 2: To determine if RT impacts appetite-related peptides, ratings, and food intake behaviors in a manner favoring reduced EI in overweight/obese adults.
Hypothesis: Compared to pre, post-RT measures will show changes in appetite-related peptides, ratings (↓ hunger ↑ satiety), and behaviors (↓food-related cravings \& impulsivity, ↑ self-efficacy) consistent with EI reduction. Changes in appetite regulation indices will be associated with changes in relevant brain networks (Aim 1). These changes will also be associated with ↓ ad libitum EI.
Exploratory Aim: To determine if RT impacts neuronal function and appetite-related peptides and behaviors in a manner favoring ↓ EI in Non-Compensators (top tertile of fat mass loss) as compared to Compensators (bottom tertile of fat mass loss).
Hypothesis: Compared to Compensators, Non-Compensators will show ↓ neuronal responses to food cues and default network, and changes in appetite-related peptides, ratings, and behaviors consistent with ↓ EI.
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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All Participants
12-weeks of a full body resistance training intervention. Intervention will consist of 4 training sessions per week that are approximately 45-minutes in length. Two days will be upper body training and 2 days lower body
Resistance Training
12-weeks of a full body resistance training intervention. Intervention will consist of 4 training sessions per week that are approximately 45-minutes in length. Two days will be upper body training and 2 days lower body
Interventions
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Resistance Training
12-weeks of a full body resistance training intervention. Intervention will consist of 4 training sessions per week that are approximately 45-minutes in length. Two days will be upper body training and 2 days lower body
Eligibility Criteria
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Inclusion Criteria
* both sexes
* age: 18-55
* BMI: 27-40 kg/m2
* weight stable (±5% in last 6 months)
* sedentary (\<2 hours of planned physical activity/week by self-report, no RT in previous 12-months)
Exclusion Criteria
* DM
* uncontrolled Hypertension
* untreated thyroid disease
* renal disease
* hepatic disease
* other condition affecting weight/metabolism
* unable to exercise
* smoker
* medications affecting weight
* EI or EE in past 6 months
* weight loss/gain \>5% in past 6 months
* post-menopausal women (defined as age appropriate women with 6 months or more of amenorrhea)
* currently pregnant, lactating, \< 6 months post-partum
* woman who have undergone oophorectomy
* bariatric surgery
* major psychiatric disorder
* alcohol or substance abuse
* depression by history and/or score \>21 on CES-D
* history of eating disorders and/or score \>20 on EATS-26
18 Years
55 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Marc-Andre Cornier, MD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
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University of Colorado Denver - Anschutz Medical Campus
Aurora, Colorado, United States
Countries
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Other Identifiers
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18-1298
Identifier Type: -
Identifier Source: org_study_id
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